Ligand D-asparagine

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Basic Ligand Information

Molecular Structure
Picture of D-asparagine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H8N2O3
D-asparagine
DCXYFEDJOCDNAF-UWTATZPHSA-N
Synonyms:
D-Asn, D-asparaginate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-asparagine + H2O = D-aspartate + NH3
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-asparagine = D-asparagine
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (26 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-asparagine + H2O = D-aspartate + NH3
show the reaction diagram
-
D-Asn = L-Asn
show the reaction diagram
-
D-alanine + D-asparagine + ATP = D-alanyl-D-asparagine + ADP + phosphate
show the reaction diagram
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ATP + D-Asn = ADP + phosphate + D-Asn-D-Asn
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N-Acetyl-D-Asn + H2O = acetate + D-Asn
show the reaction diagram
-
-
L-asparagine = D-asparagine
show the reaction diagram
-
-

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
stimulation, 112% of non-stimulated activity
-

Inhibitor in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
93% activity in the presence of 10 mM D-asparagine
-
inhibition of D- and L-transamination of D-alanine to alpha-ketoglutarate, weak
-
mixed type of competitive and non-competitive inhibition, Ki: 7.2-8.4 mM
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3D Structure of Enzyme-Ligand-Complex (PDB) (2 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (14 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
8.87
-
pH 7.5

KM Value (25 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
7.2
-
pH 7.5

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
7.2
8.4
mixed type of competitive and non-competitive inhibition

References & Links

Links to other databases for D-asparagine

ChEBI
PubChem
ChEBI
PubChem