Ligand 5-L-glutamylaniline
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Basic Ligand Information
Molecular Structure

C11H14N2O3
5-L-glutamylaniline
VMNRUJGOLBSEPK-VIFPVBQESA-N
5-L-glutamyl-anilide, beta-N-(gamma-L-glutamyl)phenylhydrazine, L-gamma-glutamylaniline, N5-phenyl-L-glutamine
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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N5-phenyl-L-glutamine + H2O = L-glutamate + aniline
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)
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ATP + L-glutamate + aniline = ADP + phosphate + N5-phenyl-L-glutamine
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Substrate in Enzyme-catalyzed Reactions (7 results)
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5-L-glutamylaniline + 5-L-glutamylaniline = aniline + 5-L-glutamyl-5-L-glutamylaniline
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5-L-glutamylaniline + H2O = aniline + L-glutamic acid
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5-L-glutamylaniline + S-methyl-L-cysteine = aniline + 5-L-glutamyl-S-methyl-L-cysteine
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L-gamma-glutamylaniline = ?
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beta-N-(gamma-L-glutamyl)phenylhydrazine + H2O = L-glutamate + phenylhydrazine
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N5-phenyl-L-glutamine + H2O = L-glutamate + aniline
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5-L-glutamyl-anilide = 5-oxoproline + aniline
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Product in Enzyme-catalyzed Reactions (2 results)
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glutamine + phenylhydrazine = beta-N-(gamma-L-glutamyl)phenylhydrazine
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ATP + L-glutamate + aniline = ADP + phosphate + N5-phenyl-L-glutamine
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (2 results)
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0.036
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pH and temperature not specified in the publication
0.036
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pH and temperature not specified in the publication
KM Value (2 results)
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0.1
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pH and temperature not specified in the publication
0.1
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pH and temperature not specified in the publication
References & Links
Literature References (4)
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gamma-Glutamyl transpeptidase from kidney bean fruit. I. Purification and mechanism of action
1967
Goore, M.Y.; Thompson, J.F.
Biochim. Biophys. Acta
132
15-26
Studies on the gamma-glutamyltransferase of Agaricus bisporus
1964
Gigliotti, H.J.; Levenberg, B.
J. Biol. Chem.
239
2274-2284
Probing the specificity of gamma-glutamylamine cyclotransferase: an enzyme involved in the metabolism of transglutaminase-catalyzed protein crosslinks
2013
Bowser, T.E.; Trawick, M.L.
Amino Acids
44
143-150
Function of a glutamine synthetase-like protein in bacterial aniline oxidation via gamma-glutamylanilide
2013
Takeo, M.; Ohara, A.; Sakae, S.; Okamoto, Y.; Kitamura, C.; Kato, D.; Negoro, S.
J. Bacteriol.
195
4406-4414
Links to other databases for 5-L-glutamylaniline