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Studies on sepiapterin deaminase from the silkworm, Bombyx mori. Purification and some properties of the enzyme
1971
Tsusue, M.
J. Biochem.
69
781-788
Sepiapterin reductase from horse liver: purification and properties of the enzyme
1971
Katoh, S.
Arch. Biochem. Biophys.
146
202-214
-
A new enzyme from Drosophila melanogaster: in vitro conversion of xanthommatin into its dihydroform by means of xanthommatin reductase
1986
Santoro, P.; Parisi, G.
J. Exp. Zool.
239
169-173
-
Biosynthesis of dihydroxanthommatin
1987
Santoro, P.; Parisi, G.
Insect Biochem.
17
635-638
-
The occurence and properties of pteridine reductase: dihydrofolate reductase in Crithidia fasciculata
1983
Oe, H.; Kohashi, M.; Iwai, K.
Agric. Biol. Chem.
47
251-258
The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major
1997
Nare, B.; Hardy, L.W.; Beverley, S.M.
J. Biol. Chem.
272
13883-13891
A pteridine reductase gene ptr1 contiguous to a P-glycoprotein confers resistance to antifolates in Trypanosoma cruzi
1997
Robello, C.; Navarro, P.; Castanys, S.; Gamarro, F.
Mol. Biochem. Parasitol.
90
525-535
-
New approaches to Leishmania chemotherapy: pteridine reductase 1 (PTR1) as a target and modulator of antifolate sensitivity
1997
Nare, B.; Luba, J.; Hardy, L.W.; Beverley, S.
Parasitology
114
101-110
Biochemical and genetic tests for inhibitors of Leishmania pteridine pathways
1997
Hardy, L.W.; Matthews, W.; Nare, B.; Beverley, S.M.
Exp. Parasitol.
87
157-169
Residues involved in co-factor and substrate binding of the short-chain dehydrogenase/reductase PTR1 producing methotrexate resistance in Leishmania
1998
Leblanc, E.; Papadopoulou, B.; Bernatchez, C.; Ouellette, M.
Eur. J. Biochem.
251
768-774
PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major
1994
Bello, A.R.; Nare, B.; Freedman, D.; Hardy, L.; Beverly, S.M.
Proc. Natl. Acad. Sci. USA
91
11442-11446
Pterin and folate reduction by the Leishmania tarentolae H locus short-chain dehydrogenase/reductase PTR1
1997
Wang, J.; Leblanc, E.; Chang, C.F.; Papadopoulou, B.; Bray, T.; Witheley, J.M.; Lin, S.X.; Quellette, M.
Arch. Biochem. Biophys.
342
197-202
Leishmania major pteridine reductase 1 belongs to the short chain dehydrogenase family: stereochemical and kinetic evidence
1998
Luba, J.; Nare, B.; Liang, P.H.; Anderson, K.S.; Beverley, S.M.; Hardy, L.W.
Biochemistry
37
4093-4104
Structure of pteridine reductase (PTR1) from Leishmania tarentolae
2003
Zhao, H.; Bray, T.; Ouellette, M.; Zhao, M.; Ferre, R.A.; Matthews, D.; Whiteley, J.M.; Varughese, K.I.
Acta Crystallogr. Sect. D
59
1539-1544
Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate
2006
Dawson, A.; Gibellini, F.; Sienkiewicz, N.; Tulloch, L.B.; Fyfe, P.K.; McLuskey, K.; Fairlamb, A.H.; Hunter, W.N.
Mol. Microbiol.
61
1457-1468
Molecular docking, structure-activity relationship and biological evaluation of the anticancer drug monastrol as a pteridine reductase inhibitor in a clinical isolate of Leishmania donovani
2010
Kaur, J.; Sundar, S.; Singh, N.
J. Antimicrob. Chemother.
65
1742-1748
Differential heterocyclic substrate recognition by, and pteridine inhibition of E. coli and human tRNA-guanine transglycosylases
2011
Eric Thomas, C.; Chen, Y.C.; Garcia, G.A.
Biochem. Biophys. Res. Commun.
410
34-39
Structure of recombinant Leishmania donovani pteridine reductase reveals a disordered active site
2011
Barrack, K.L.; Tulloch, L.B.; Burke, L.A.; Fyfe, P.K.; Hunter, W.N.
Acta Crystallogr. Sect. F
67
33-37
Design, synthesis and biological evaluation of novel inhibitors of Trypanosoma brucei pteridine reductase 1
2011
Spinks, D.; Ong, H.B.; Mpamhanga, C.P.; Shanks, E.J.; Robinson, D.A.; Collie, I.T.; Read, K.D.; Frearson, J.A.; Wyatt, P.G.; Brenk, R.; Fairlamb, A.H.; Gilbert, I.H.
ChemMedChem
6
302-308
Molecular cloning, expression and enzymatic assay of pteridine reductase 1 from Iranian lizard Leishmania
2010
Kazemi, B.; Tohidi, F.; Bandehpour, M.; Yarian, F.
Iran. Biomed. J.
14
97-102
Dissecting the metabolic roles of pteridine reductase 1 in Trypanosoma brucei and Leishmania major
2011
Ong, H.B.; Sienkiewicz, N.; Wyllie, S.; Fairlamb, A.H.
J. Biol. Chem.
286
10429-10438
An integrated approach towards the discovery of novel non-nucleoside Leishmania major pteridine reductase 1 inhibitors
2017
Leite, F.H.A.; Froes, T.Q.; da Silva, S.G.; de Souza, E.I.M.; Vital-Fujii, D.G.; Trossini, G.H.G.; Pita, S.S.D.R.; Castilho, M.S.
Eur. J. Med. Chem.
132
322-332
Molecular characterization and functional analysis of pteridine reductase in wild-type and antimony-resistant Leishmania lines
2016
de Souza Moreira, D.; Ferreira, R.F.; Murta, S.M.
Exp. Parasitol.
160
60-66
Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1
2014
Khalaf, A.I.; Huggan, J.K.; Suckling, C.J.; Gibson, C.L.; Stewart, K.; Giordani, F.; Barrett, M.P.; Wong, P.E.; Barrack, K.L.; Hunter, W.N.
J. Med. Chem.
57
6479-6494
Chroman-4-one derivatives targeting pteridine reductase 1 and showing anti-parasitic activity
2017
Di Pisa, F.; Landi, G.; Dello Iacono, L.; Pozzi, C.; Borsari, C.; Ferrari, S.; Santucci, M.; Santarem, N.; Cordeiro-Da-Silva, A.; Moraes, C.; Alcantara, L.; Fontana, V.; Freitas-Junior, L.; Gul, S.; Kuzikov, M.; Behrens, B.; Poehner, I.; Wade, R.; Costi,
Molecules
22
E426
Substrate and inhibitor specificity of tRNA-guanine ribosyltransferase
1984
Farkas, W.; Jacobson, K.; Katze, J.
Biochim. Biophys. Acta
781
64-75