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Studies on sepiapterin deaminase from the silkworm, Bombyx mori. Purification and some properties of the enzyme
1971
Tsusue, M.
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A new enzyme from Drosophila melanogaster: in vitro conversion of xanthommatin into its dihydroform by means of xanthommatin reductase
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Biosynthesis of dihydroxanthommatin
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The occurence and properties of pteridine reductase: dihydrofolate reductase in Crithidia fasciculata
1983
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The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major
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A pteridine reductase gene ptr1 contiguous to a P-glycoprotein confers resistance to antifolates in Trypanosoma cruzi
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New approaches to Leishmania chemotherapy: pteridine reductase 1 (PTR1) as a target and modulator of antifolate sensitivity
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Residues involved in co-factor and substrate binding of the short-chain dehydrogenase/reductase PTR1 producing methotrexate resistance in Leishmania
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PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major
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Bello, A.R.; Nare, B.; Freedman, D.; Hardy, L.; Beverly, S.M.
Proc. Natl. Acad. Sci. USA
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Pterin and folate reduction by the Leishmania tarentolae H locus short-chain dehydrogenase/reductase PTR1
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Leishmania major pteridine reductase 1 belongs to the short chain dehydrogenase family: stereochemical and kinetic evidence
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Biochemistry
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Structure of pteridine reductase (PTR1) from Leishmania tarentolae
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Acta Crystallogr. Sect. D
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Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate
2006
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Leishmania donovani pteridine reductase 1: biochemical properties and structure-modeling studies
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Molecular docking, structure-activity relationship and biological evaluation of the anticancer drug monastrol as a pteridine reductase inhibitor in a clinical isolate of Leishmania donovani
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Differential heterocyclic substrate recognition by, and pteridine inhibition of E. coli and human tRNA-guanine transglycosylases
2011
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Structure of recombinant Leishmania donovani pteridine reductase reveals a disordered active site
2011
Barrack, K.L.; Tulloch, L.B.; Burke, L.A.; Fyfe, P.K.; Hunter, W.N.
Acta Crystallogr. Sect. F
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Design, synthesis and biological evaluation of novel inhibitors of Trypanosoma brucei pteridine reductase 1
2011
Spinks, D.; Ong, H.B.; Mpamhanga, C.P.; Shanks, E.J.; Robinson, D.A.; Collie, I.T.; Read, K.D.; Frearson, J.A.; Wyatt, P.G.; Brenk, R.; Fairlamb, A.H.; Gilbert, I.H.
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Molecular cloning, expression and enzymatic assay of pteridine reductase 1 from Iranian lizard Leishmania
2010
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Iran. Biomed. J.
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Dissecting the metabolic roles of pteridine reductase 1 in Trypanosoma brucei and Leishmania major
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An integrated approach towards the discovery of novel non-nucleoside Leishmania major pteridine reductase 1 inhibitors
2017
Leite, F.H.A.; Froes, T.Q.; da Silva, S.G.; de Souza, E.I.M.; Vital-Fujii, D.G.; Trossini, G.H.G.; Pita, S.S.D.R.; Castilho, M.S.
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Molecular characterization and functional analysis of pteridine reductase in wild-type and antimony-resistant Leishmania lines
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de Souza Moreira, D.; Ferreira, R.F.; Murta, S.M.
Exp. Parasitol.
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Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1
2014
Khalaf, A.I.; Huggan, J.K.; Suckling, C.J.; Gibson, C.L.; Stewart, K.; Giordani, F.; Barrett, M.P.; Wong, P.E.; Barrack, K.L.; Hunter, W.N.
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Chroman-4-one derivatives targeting pteridine reductase 1 and showing anti-parasitic activity
2017
Di Pisa, F.; Landi, G.; Dello Iacono, L.; Pozzi, C.; Borsari, C.; Ferrari, S.; Santucci, M.; Santarem, N.; Cordeiro-Da-Silva, A.; Moraes, C.; Alcantara, L.; Fontana, V.; Freitas-Junior, L.; Gul, S.; Kuzikov, M.; Behrens, B.; Poehner, I.; Wade, R.; Costi,
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Substrate and inhibitor specificity of tRNA-guanine ribosyltransferase
1984
Farkas, W.; Jacobson, K.; Katze, J.
Biochim. Biophys. Acta
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