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Ligand adipyl 6-aminopenicillanic acid

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.20.1

adipyl-6-aminopenicillanic acid + 2-oxoglutarate + O2 = 7-adipylaminodesacetoxycephalosporanic acid + succinate + CO2 + H2O

699366

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Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.20.1

adipyl-6-aminopenicillanic acid + 2-oxoglutarate + O2 = 7-adipylaminodesacetoxycephalosporanic acid + succinate + CO2 + H2O

699366, 440373

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1.14.20.1

adipyl-6-aminopenicillanic acid + 2-oxoglutarate + O2 = ? + succinate + CO2 + H2O

659322

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1.14.20.1

2 entries

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

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Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

1.14.20.1

0.073

-

-

440373

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.14.20.1

1.3

-

-

440373

References & Links

Literature References (3)

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Show Reference (3 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

440373

10222202

Studies on the active site of deacetoxycephalosporin C synthase

1999

Lloyd, M.D.; Lee, H.J.; Harlos, K.; Zhang, Z.H.; Baldwin, J.E.; Schofield, C.J.; Charnock, J.M.; Garner, C.D.; Hara, T.; Terwisscha van Scheltinga, A.C.; Valeg.Ang.rd, K.; Viklund, J.A.C.; Hajdu, J.; Andersson, I.; Danielsson, A.; Bhikhabhai, R.

J. Mol. Biol.

287

943-960

659322

14734549

Controlling the substrate selectivity of deacetoxycephalosporin/deacetylcephalosporin C synthase

2004

Lloyd, M.D.; Lipscomb, S.J.; Hewitson, K.S.; Hensgens, C.M.H.; Baldwin, J.E.; Schofield, C.J.

J. Biol. Chem.

279

15420-15426

699366

19277744

Directed evolution and rational approaches to improving Streptomyces clavuligerus deacetoxycephalosporin C synthase for cephalosporin production

2009

Goo, K.S.; Chua, C.S.; Sim, T.S.

J. Ind. Microbiol. Biotechnol.

36

619-633

Links to other databases for adipyl 6-aminopenicillanic acid

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Show Links (1 entry)

ChEBI

PubChem

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