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Ligand 5-hydroperoxyeicosatetraenoic acid

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Natural Substrate (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.11.1.9

5-hydroperoxyeicosatetraenoic acid + 2 GSH = 5-hydroxyeicosatetraenoic acid + GSSG + H2O

396643, 396637

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1.13.11.34

5-hydroperoxyeicosatetraenoic acid = leukotriene A4 + H2O

688104

-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.13.11.34

arachidonic acid + O2 = 5-hydroperoxyeicosatetraenoic acid

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Substrate in Enzyme-catalyzed Reactions (4 results)

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Show Substrate (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.11.1.9

5-hydroperoxyeicosatetraenoic acid + 2 GSH = 5-hydroxyeicosatetraenoic acid + GSSG + H2O

396643, 396637

-

1.13.11.34

5-hydroperoxyeicosatetraenoic acid = leukotriene A4 + H2O

688104

-

1.13.11.40

5-hydroperoxyeicosatetraenoic acid + ? = leukotriene A4

439401

-

5.3.99.3

5-hydroperoxyeicosatetraenoic acid + 2 GSH = 5-hydroxyeicosatetraenoic acid + GSSG + H2O

652399

-

Product in Enzyme-catalyzed Reactions (1 result)

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Show Product (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.13.11.34

arachidonic acid + O2 = 5-hydroperoxyeicosatetraenoic acid

-

-

Enzyme Kinetic Parameters

References & Links

Literature References (5)

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Show Reference (5 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

396637

10549853

Cellular glutathione peroxidase as a predominant scavenger of hydroperoxyeicosatetraenoic acids in rabbit alveolar macrophages

1999

Chiba, N.; Imai, H.; Narashima, K.; Arai, M.; Oshima, G.I.; Kunimoto, M.; Nakagawa, Y.

Biol. Pharm. Bull.

22

1047-1051

396643

8204670

Purification and characterization of glutathione peroxidase from human blood platelets. Age-related changes in the enzyme

1994

Rey, C.; Vericel, E.; Nemoz, G.; Chen, W.; Chapuy, P.; Lagarde, M.

Biochim. Biophys. Acta

1226

219-224

439401

10216287

Leukotriene A synthase activity of purified mouse skin arachidonate 8-lipoxygenase expressed in Escherichia coli

1999

Qiao, N.; Takahashi, Y.; Takamatsu, H.; Yoshimoto, T.

Biochim. Biophys. Acta

1438

131-139

652399

12672824

Human microsomal prostaglandin E synthase-1: purification, functional characterization, and projection structure determination

2003

Thoren, S.; Weinander, R.; Saha, S.; Jegerschoeld, C.; Pettersson, P.L.; Samuelsson, B.; Hebert, H.; Hamberg, M.; Morgenstern, R.; Jakobsson, P.J.

J. Biol. Chem.

278

22199-22209

688104

18038760

Methyl jasmonate induced apoptosis in human prostate carcinoma cells via 5-lipoxygenase dependent pathway

2007

Ezekwudo, D.E.; Wang, R.C.; Elegbede, J.A.

J. Exp. Ther. Oncol.

6

267-277

Links to other databases for 5-hydroperoxyeicosatetraenoic acid

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Show Links (1 entry)

ChEBI

PubChem

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