Ligand tetrachlorohydroquinone

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Basic Ligand Information

Molecular Structure
Picture of tetrachlorohydroquinone (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H2ClO2
tetrachlorohydroquinone
STOSPPMGXZPHKP-UHFFFAOYSA-N
Synonyms:
2,3,5,6-tetrachloro-p-hydroquinone, 2,3,5,6-tetrachlorobenzoquinol, 2,3,5,6-tetrachlorohydroquinone, tetrachloro-p-benzoquinol

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2,3,5,6-tetrachlorohydroquinone + NAD+ = 2,3,5,6-tetrachloro-1,4-benzoquinone + NADH + H+
show the reaction diagram
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2,3,5,6-tetrachlorohydroquinone + 2 glutathione = 2,3,6-trichlorohydroquinone + Cl- + glutathione disulfide
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2,3,5,6-tetrachloro-1,4-benzoquinone + NADH + H+ = 2,3,5,6-tetrachlorohydroquinone + NAD+
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
tetrachlorohydroquinone + O2 = ?
show the reaction diagram
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2,3,5,6-tetrachlorohydroquinone + 2 glutathione = 2,3,6-trichlorohydroquinone + Cl- + glutathione disulfide
show the reaction diagram
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2,3,5,6-tetrachlorobenzoquinol + oxidized dithiothreitol = ?
show the reaction diagram
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tetrachlorohydroquinone/in + ATP + H2O = tetrachlorohydroquinone/out + ADP + phosphate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2,3,5,6-tetrachloro-1,4-benzoquinone + NADH + H+ = 2,3,5,6-tetrachlorohydroquinone + NAD+
show the reaction diagram
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tetrachlorohydroquinone/in + ATP + H2O = tetrachlorohydroquinone/out + ADP + phosphate
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activity of PcpD is stimulated by tetrachlorohydroquinone at low concentrations but inhibited at high concentrations. 83% increase in activity at 0.1 mM tetrachlorohydroquinone, 60% loss of activity at 0.2 mM tetrachlorohydroquinone
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Inhibitor in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activity of PcpD is stimulated by tetrachlorohydroquinone at low concentrations but inhibited at high concentrations. 83% increase in activity at 0.1 mM tetrachlorohydroquinone, 60% loss of activity at 0.2 mM tetrachlorohydroquinone
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competitive inhibition
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Enzyme Kinetic Parameters

kcat Value (Turnover Number) (5 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (5 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (3 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.003
-
pH 7.0, 20°C, mutant enzyme C156S

References & Links

Links to other databases for tetrachlorohydroquinone

ChEBI
PubChem
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PubChem