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Ligand dTDP-6-deoxy-L-lyxo-4-hexulose

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.133

dTDP-6-deoxy-L-lyxo-4-hexulose + NADPH = dTDP-L-rhamnose + NADP+

285844

-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

5.1.3.13

dTDP-6-deoxy-D-xylo-4-hexulose = dTDP-6-deoxy-L-lyxo-4-hexulose

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-

Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Substrate (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.133

dTDP-6-deoxy-L-lyxo-4-hexulose + NAD(P)H = dTDP-L-rhamnose + NAD(P)+

285846

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1.1.1.133

dTDP-6-deoxy-L-lyxo-4-hexulose + NADPH = dTDP-L-rhamnose + NADP+

285845, 285844

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1.1.1.133

2 entries

1.1.1.344

dTDP-6-deoxy-L-lyxo-4-hexulose + NADH + H+ = dTDP-6-deoxy-beta-L-talose + NAD+

285845

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Product in Enzyme-catalyzed Reactions (2 results)

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Show Product (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

5.1.3.13

dTDP-6-deoxy-D-xylo-4-hexulose = dTDP-6-deoxy-L-lyxo-4-hexulose

285846, -

-

5.1.3.13

TDP-6-deoxy-D-xylo-4-hexosulose = TDP-6-deoxy-L-lyxo-4-hexosulose

2254, 2255

-

5.1.3.13

2 entries

Enzyme Kinetic Parameters

References & Links

Literature References (5)

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Show Reference (5 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

2254

4199258

Biological mechanisms involved in the formation of deoxy sugars. VII. Biosynthesis of 6-deoxy-L-talose

1973

Gaugler, R.W.; Gabriel, O.

J. Biol. Chem.

248

6041-6049

2255

9209071

Cloning and characterization of the Streptomyces peucetius dnmZUV genes encoding three enzymes required for biosynthesis of the daunorubicin precursor thymidine diphospho-L-daunosamine

1997

Otten, S.L.; Gallo, M.A.; Madduri, K.; Liu, X.; Hutchinson, C.R.

J. Bacteriol.

179

4446-4450

285844

-

Overexpression, purification, crystallization and preliminary structural study of dTDP-6-deoxy-L-lyxo-4-hexulose reductase (RmlD), the fourth enzyme of the dTDP-L-rhamnose synthesis pathway, from Salmonella enterica serovar typhimurium

1999

Giraud, M.F.; McMiken, H.J.; Leonard, G.A.; Messner, P.; Whitfield, C.; Naismith, J.H.

Acta Crystallogr. Sect. D

55

2043-2046

285845

10702238

Thymidine diphosphate-6-deoxy-L-lyxo-4-hexulose reductase synthesizing dTDP-6-deoxy-L-talose from Actinobacillus actinomycetemcomitans

2000

Nakano, Y.; Suzuki, N.; Yoshida, Y.; Nezu, T.; Yamashita, Y.; Koga, T.

J. Biol. Chem.

275

6806-6812

285846

10455186

Characterization of dTDP-4-dehydrorhamnose 3,5-epimerase and dTDP-4-dehydrorhamnose reductase, required for dTDP-L-rhamnose biosynthesis in Salmonella enterica serovar typhimurium LT2

1999

Graninger, M.; Nidetzky, B.; Heinrichs, D.E.; Whitfield, C.; Messner, P.

J. Biol. Chem.

274

25069-25077

Links to other databases for dTDP-6-deoxy-L-lyxo-4-hexulose

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