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Ligand 2,6-di-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.265

palmitoyl-CoA + 2,6-di-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol = CoA + 2-O-(6-O-palmitoyl-alpha-D-mannosyl)-6-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol

755684, 756084

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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.346

GDP-alpha-D-mannose + 2-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol = GDP + 2,6-di-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol

0

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Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Substrate (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.265

palmitoyl-CoA + 2,6-di-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol = CoA + 2-O-(6-O-palmitoyl-alpha-D-mannosyl)-6-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol

742827, 755684, 756084, 743339, 743729

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Product in Enzyme-catalyzed Reactions (1 result)

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Show Product (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.346

GDP-alpha-D-mannose + 2-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol = GDP + 2,6-di-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol

0

-

Enzyme Kinetic Parameters

References & Links

Literature References (5)

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Show Reference (5 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

742827

12851411

Identification of the required acyltransferase step in the biosynthesis of the phosphatidylinositol mannosides of Mycobacterium species

2003

Kordulakova, J.; Gilleron, M.; Puzo, G.; Brennan, P.J.; Gicquel, B.; Mikusova, K.; Jackson, M.

J. Biol. Chem.

278

36285-36295

743339

26965057

Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA

2016

Albesa-Jove, D.; Svetlikova, Z.; Tersa, M.; Sancho-Vaello, E.; Carreras-Gonzalez, A.; Bonnet, P.; Arrasate, P.; Eguskiza, A.; Angala, S.K.; Cifuente, J.O.; Kordulakova, J.; Jackson, M.; Mikusova, K.; Guerin, M.E.

Nat. Commun.

7

10906

743729

24810911

Purification and characterization of the acyltransferase involved in biosynthesis of the major mycobacterial cell envelope glycolipid-monoacylated phosphatidylinositol dimannoside

2014

Svetlikova, Z.; Barath, P.; Jackson, M.; Kordulakova, J.; Mikusova, K.

Protein Expr. Purif.

100

33-39

755684

29185694

The molecular mechanism of substrate recognition and catalysis of the membrane acyltransferase PatA from Mycobacteria

2018

Tersa, M.; Raich, L.; Albesa-Jove, D.; Trastoy, B.; Prandi, J.; Gilleron, M.; Rovira, C.; Guerin, M.E.

ACS Chem. Biol.

13

131-140

756084

27826050

Structural basis of phosphatidyl-myo-inositol mannosides biosynthesis in mycobacteria

2017

Sancho-Vaello, E.; Albesa-Jove, D.; Rodrigo-Unzueta, A.; Guerin, M.

Biochim. Biophys. Acta

1862

1355-1367

Links to other databases for 2,6-di-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol

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Show Links (1 entry)