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Ligand 2-O-(alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Natural Substrate (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.265

palmitoyl-CoA + 2-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol = CoA + 2-O-(6-O-palmitoyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol

755684, 756084

-

2.4.1.346

GDP-alpha-D-mannose + 2-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol = GDP + 2,6-di-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol

740615

-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.345

GDP-alpha-D-mannose + 1-phosphatidyl-1D-myo-inositol = GDP + 2-O-(alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol

0

-

Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.265

palmitoyl-CoA + 2-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol = CoA + 2-O-(6-O-palmitoyl-alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol

742827, 755684, 756084, 743339, 743729

-

2.4.1.346

GDP-alpha-D-mannose + 2-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol = GDP + 2,6-di-O-alpha-D-mannosyl-1-phosphatidyl-1D-myo-inositol

704533, 719899, 740615, 740664

-

Product in Enzyme-catalyzed Reactions (2 results)

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Show Product (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.345

GDP-alpha-D-mannose + 1-phosphatidyl-1D-myo-inositol = GDP + 2-O-(alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol

0

-

2.4.1.345

GDP-alpha-D-mannose + 1-phosphatidyl-myo-inositol = GDP + 2-O-(alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol

0

-

2.4.1.345

2 entries

Enzyme Kinetic Parameters

References & Links

Literature References (9)

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Show Reference (9 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

704533

19638342

New insights into the early steps of phosphatidylinositol mannoside biosynthesis in mycobacteria: PimB is an essential enzyme of Mycobacterium smegmatis

2009

Guerin, M.E.; Kaur, D.; Somashekar, B.S.; Gibbs, S.; Gest, P.; Chatterjee, D.; Brennan, P.J.; Jackson, M.

J. Biol. Chem.

284

25687-25696

719899

20843801

Acceptor substrate discrimination in phosphatidyl-myo-inositol mannoside synthesis: structural and mutational analysis of mannosyltransferase Corynebacterium glutamicum PimB

2010

Batt, S.M.; Jabeen, T.; Mishra, A.K.; Veerapen, N.; Krumbach, K.; Eggeling, L.; Besra, G.S.; Fuetterer, K.

J. Biol. Chem.

285

37741-37752

740615

19395496

Characterization of the Corynebacterium glutamicum deltapimB deltamgtA double deletion mutant and the role of Mycobacterium tuberculosis orthologues Rv2188c and Rv0557 in glycolipid biosynthesis

2009

Mishra, A.K.; Batt, S.; Krumbach, K.; Eggeling, L.; Besra, G.S.

J. Bacteriol.

191

4465-4472

740664

10531370

The pimB gene of Mycobacterium tuberculosis encodes a mannosyltransferase involved in lipoarabinomannan biosynthesis

1999

Schaeffer, M.L.; Khoo, K.H.; Besra, G.S.; Chatterjee, D.; Brennan, P.J.; Belisle, J.T.; Inamine, J.M.

J. Biol. Chem.

274

31625-31631

742827

12851411

Identification of the required acyltransferase step in the biosynthesis of the phosphatidylinositol mannosides of Mycobacterium species

2003

Kordulakova, J.; Gilleron, M.; Puzo, G.; Brennan, P.J.; Gicquel, B.; Mikusova, K.; Jackson, M.

J. Biol. Chem.

278

36285-36295

743339

26965057

Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA

2016

Albesa-Jove, D.; Svetlikova, Z.; Tersa, M.; Sancho-Vaello, E.; Carreras-Gonzalez, A.; Bonnet, P.; Arrasate, P.; Eguskiza, A.; Angala, S.K.; Cifuente, J.O.; Kordulakova, J.; Jackson, M.; Mikusova, K.; Guerin, M.E.

Nat. Commun.

7

10906

743729

24810911

Purification and characterization of the acyltransferase involved in biosynthesis of the major mycobacterial cell envelope glycolipid-monoacylated phosphatidylinositol dimannoside

2014

Svetlikova, Z.; Barath, P.; Jackson, M.; Kordulakova, J.; Mikusova, K.

Protein Expr. Purif.

100

33-39

755684

29185694

The molecular mechanism of substrate recognition and catalysis of the membrane acyltransferase PatA from Mycobacteria

2018

Tersa, M.; Raich, L.; Albesa-Jove, D.; Trastoy, B.; Prandi, J.; Gilleron, M.; Rovira, C.; Guerin, M.E.

ACS Chem. Biol.

13

131-140

756084

27826050

Structural basis of phosphatidyl-myo-inositol mannosides biosynthesis in mycobacteria

2017

Sancho-Vaello, E.; Albesa-Jove, D.; Rodrigo-Unzueta, A.; Guerin, M.

Biochim. Biophys. Acta

1862

1355-1367

Links to other databases for 2-O-(alpha-D-mannosyl)-1-phosphatidyl-1D-myo-inositol

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Show Links (1 entry)