Ligand [histone H3]-N6-acetyl-L-lysine18
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Basic Ligand Information
[histone H3]-N6-acetyl-L-lysine18
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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NAD+ + [histone H3]-N6-acetyl-L-lysine18 = nicotinamide + [histone H3]-L-lysine + 2'-O-acetyl-ADP ribose
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)
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acetyl-CoA + [histone H3]-L-lysine18 = CoA + [histone H3]-N6-acetyl-L-lysine18
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Substrate in Enzyme-catalyzed Reactions (2 results)
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[histone H3]-N6-acetyl-L-lysine18 + NAD+ + H2O = [histone H3]-L-lysine18 + 2''-O-acetyl-ADP-D-ribose + nicotinamide
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NAD+ + [histone H3]-N6-acetyl-L-lysine18 = nicotinamide + [histone H3]-L-lysine + 2'-O-acetyl-ADP ribose
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Product in Enzyme-catalyzed Reactions (1 result)
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acetyl-CoA + [histone H3]-L-lysine18 = CoA + [histone H3]-N6-acetyl-L-lysine18
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Enzyme Kinetic Parameters
References & Links
Literature References (2)
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SIRT6 deacetylates H3K18Ac at pericentric chromatin to prevent mitotic errors and cellular senescence
2016
Tasselli, L.; Xi, Y.; Zheng, W.; Tennen, R.I.; Odrowaz, Z.; Simeoni, F.; Li, W.; Chua, K.F.
Nat. Struct. Mol. Biol.
23
434-440
Histone deacetylation by Sir2 generates a transcriptionally repressed nucleoprotein complex
2003
Parsons, X.H.; Garcia, S.N.; Pillus, L.; Kadonaga, J.T.
Proc. Natl. Acad. Sci. USA
100
1609-1614
Links to other databases for [histone H3]-N6-acetyl-L-lysine18