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Ligand 3-oxopentanoate Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information
C5 H8 O3
3-oxopentanoate
FHSUFDYFOHSYHI-UHFFFAOYSA-N
Roles as Enzyme Ligand
In Vivo Product in Enzyme-catalyzed Reactions (1 result)Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
butanone + CO2 + ATP + H2O = 3-oxopentanoate + AMP + phosphate
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Substrate in Enzyme-catalyzed Reactions (3 results)
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3-oxopentanoate + 2-aminobenzoyl-CoA = CoA + 2-ethyl-4(1H)-quinolone + CO2 + H2O
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butanoyl-CoA + 3-oxopentanoate = butanoate + 3-oxopentanoyl-CoA
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3-oxopentanoate + H+ = 2-butanone + CO2
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Product in Enzyme-catalyzed Reactions (2 results)
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3-hydroxyvalerate + NAD+ = 3-oxovalerate + NADH + H+
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butanone + CO2 + ATP + H2O = 3-oxopentanoate + AMP + phosphate
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3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)
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Enzyme Kinetic Parameters
References & Links Literature References (6)
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Assay and properties of acetone carboxylase, a novel enzyme involved in acetone-dependent growth and CO2 fixation in Rhodobacter capsulatus and other photosynthetic and denitrifying bacteria
1997
Birks, S.J.; Kelly, D.J.
Microbiology
143
755-766
Evidence for an inducible nucleotide-dependent acetone carboxylase in Rhodococcus rhodochrous B276
1999
Clark, D.D.; Ensign, S.A.
J. Bacteriol.
181
2752-2758
Purification and characterization of acetone carboxylase from Xanthobacter strain Py2
1997
Sluis, M.K.; Ensign, S.A.
Proc. Natl. Acad. Sci. USA
94
8456-8461
Butyryl-CoA:acetoacetate CoA-transferase from a lysine-fermenting Clostridium
1978
Barker, H.A.; Jemg, I.M.; Neff, N.; Robertson, J.M.; Tam, F.K.; Hosaka, S.
J. Biol. Chem.
253
1219-1225
Volatile ketone formation in bacteria: release of 3-oxopentanoate by soil pseudomonads during growth on heptanoate
2001
Matiasek M.G.; Choudhury K.; Nemecek-Marshall, M.; Fall, R.
Curr. Microbiol.
42
276-281
Biosynthesis of 2-Alkyl-4(1H)-quinolones in Pseudomonas aeruginosa: potential for therapeutic interference with pathogenicity
2011
Pistorius, D.; Ullrich, A.; Lucas, S.; Hartmann, R.W.; Kazmaier, U.; Müller, R.
Chembiochem
12
850-853
Links to other databases for 3-oxopentanoate
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