Ligand D-glutamine

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Basic Ligand Information

Molecular Structure
Picture of D-glutamine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H10N2O3
D-glutamine
ZDXPYRJPNDTMRX-GSVOUGTGSA-N
Synonyms:
(2R)-2,5-diamino-5-oxopentanoic acid, D-Gln
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-glutamine + H2O = D-glutamate + NH3
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2 ATP + 2 L-glutamate + 2 NH3 = 2 ADP + 2 phosphate + D-glutamine + D-isoglutamine
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (32 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-glutamine + oxidized 2,6-dichloroindophenol + H2O = 4-carbamoyl-2-oxobutanoate + NH3 + reduced 2,6-dichloroindophenol
show the reaction diagram
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D-glutamine + D-glutamyl-peptide = NH3 + 5-glutamyl-D-glutamyl-peptide
show the reaction diagram
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D-glutamine + H2O = D-glutamate + NH3
show the reaction diagram
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D-glutamine + H2O = D-glutamate + NH3
show the reaction diagram
-
D-glutamine + H2O = D-glutamate + NH3
show the reaction diagram
-
D-glutamine + H2O = D-glutamate + NH3
show the reaction diagram
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D-Gln = L-Gln
show the reaction diagram
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D-alanine + D-glutamine + ATP = D-alanyl-D-glutamine + ADP + phosphate
show the reaction diagram
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ATP + D-Gln = ADP + phosphate + D-Gln-D-Gln
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-glutamine = D-glutamine
show the reaction diagram
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L-glutamine = D-glutamine
show the reaction diagram
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-
2 ATP + 2 L-glutamate + 2 NH3 = 2 ADP + 2 phosphate + D-glutamine + D-isoglutamine
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
95% activity in the presence of 10 mM D-glutamine
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20 mM: 20% inhibition
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competitive
weak
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3D Structure of Enzyme-Ligand-Complex (PDB) (3 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (6 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
3.17
-
-
1362
-
at pH 8.5 and 85°C

KM Value (16 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.278
-
-
77.6
-
at pH 8.5 and 85°C
83
-
pH 9.0, at 37ºC, H2O as co-substrate
7.8
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-

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.3
-
-
50
-
-

References & Links

Links to other databases for D-glutamine

ChEBI
PubChem
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PubChem