Ligand N-acetylsphingosine

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Basic Ligand Information

Molecular Structure
Picture of N-acetylsphingosine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C20H39NO3
N-acetylsphingosine
BLTCBVOJNNKFKC-QUDYQQOWSA-N
Synonyms:
C2 ceramide, C2 ceramide 1-phosphate, C2-ceramide, C2-ceramide 1-phosphate, C2:0-ceramide, D-erythro-C2:0 ceramide, D-erythro-C2:0 ceramide 1-phosphate, N-acetyl-D-erythro-sphingenine, N-acetyl-D-erythro-sphingenine 1-phosphate, N-acetyl-sphingenine, N-acetyl-sphingenine 1-phosphate

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Activator in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
treatment of 3T3-L1 preadipocytes robustly induces the expression of isoform 11beta-HSD1 via induction of CCAAT/enhancer-binding protein beta and its binding to the 11beta-HSD1 promoter
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i.e. C2-ceramide, an intracellular mediator of apoptosis, cell-permeable N-acetylsphingosine activates mitochondrial p38 MAPK
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stimulation
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potent PP2A activator
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weaker activator than sphingosine 1-phosphate, activation at 0.000237 mM
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Inhibitor in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

KM Value (2 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for N-acetylsphingosine

ChEBI
PubChem
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PubChem