Ligand CDP

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Basic Ligand Information

Molecular Structure

Picture of CDP (click for magnification)

C₉H₁₅N₃O₁₁P₂

CDP

ZWIADYZPOWUWEW-XVFCMESISA-N

Synonyms:

5'-CDP, cytidine-5'-diphosphate, cytidine 5'-diphosphate, D-CDP

BRENDA

chlorophyll metabolism, dolichol and dolichyl phosphate biosynthesis, flavin biosynthesis, pyrimidine metabolism

KEGG

Biosynthesis of cofactors, Nucleotide metabolism, Pyrimidine metabolism

MetaCyc

CMP phosphorylation, diacylglycerol and triacylglycerol biosynthesis, dolichol and dolichyl phosphate biosynthesis, farnesylcysteine salvage pathway, flavin biosynthesis II (archaea)

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Show all BRENDA pathways known for CDP

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (30 results)

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CDP + H2O = CMP + phosphate

696153, 696275

3.6.1.5

CDP + H2O = CMP + phosphate

720442, 700083

3.6.1.6

CDP + H2O = CMP + phosphate

756218

3.6.1.9

CDP + H2O = CMP + phosphate

246817

In Vivo Product in Enzyme-catalyzed Reactions (19 results)

CDP-abequose + mannosyl-rhamnosyl-galactose-1-diphospholipid = CDP + abequosyl-mannosyl-rhamnosyl-galactose-1-diphospholipid

2.7.1.108

CTP + dolichol = CDP + dolichyl phosphate

0, 640391, 640395, 640399, 640392, 640396, 640394, 640398, 640393, 640401, 640390

2.7.1.161

3 entries

2.7.1.174

CTP + 1,2-diacyl-sn-glycerol = CDP + 1,2-diacyl-sn-glycerol 3-phosphate

2.7.1.182

CTP + phytol = CDP + phytyl phosphate

2.7.1.33

CTP + (R)-pantothenate = CDP + (R)-4'-phosphopantothenate

2.7.1.48

ATP + CMP = ADP + CDP

2.7.4.14

3 entries

2.7.4.25

ATP + CMP = ADP + CDP

7l4a, 3D-view

2.7.8.44

CDP-glycerol + N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = CDP + 4-O-((2R)-1-glycerophospho)-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol

3.6.1.15

CTP + H2O = CDP + phosphate

3.6.1.5

CTP + H2O = CDP + phosphate

5.6.1.5

CTP + H2O + polypeptide = CDP + phosphate + unfolded polypeptide

Substrate in Enzyme-catalyzed Reactions (167 results)

CDP + sucrose = CDP-alpha-D-glucose + D-fructose

756234

2.4.1.245

alpha,alpha-trehalose + CDP = CDP-alpha-D-glucose + D-glucose

747674

2.5.1.112

dimethylallyl diphosphate + CDP = ?

671796

2.5.1.27

dimethylallyl diphosphate + CDP = ?

CDP + D-glucose = CMP + D-glucose 6-phosphate

660867

2.7.1.40

CDP + phosphoenolpyruvate = CTP + pyruvate

641584, 641589, 641516, 641562, 641586, 641570, 641578, 641545, 641567, 641558, 641576

2.7.2.3

2 entries

2.7.3.8

CDP + phosphoramide = CTP + NH3

CDP + (phosphate)n+1 = CTP + (phosphate)n

762661

2.7.7.43

CDP + N-acetylneuraminate = phosphate + CMP-N-acetylneuraminate

645260, 645272, 645280, 690583

1eyr, 3D-view

2.7.7.5

CDP + phosphate = phosphate + CDP

643453

2.7.7.8

poly(C) + CDP = poly(C)+1 + phosphate

643680, 643679, 643687, 643699, 643688, 643683, 643686

3.1.3.2

CDP + H2O = CMP + phosphate

134695, 134722, 134688, 134689

3.1.3.9

glucose + CDP = glucose 6-phosphate + CMP

134941, 134945

3.1.4.16

CDP + H2O = CMP + phosphate

652555

3.1.4.37

CDP + H2O = CMP + phosphate

CDP + H2O = ?

CDP + H2O = CMP + phosphate

696153, 696275

3.6.1.29

adenosine 5'-phosphoimidazolide + CDP = imidazole + A(5')p3(5')C

655798

3.6.1.5

CDP + H2O = CMP + phosphate

720442, 210160, 210165, 210134, 210166, 654862, 210144, 210148, 210149, 210157, 696153, 210169, 210141, 209778, 210133, 700083, 755996, 210151, 210147, 655463, 669222, 734869

3.6.1.6

CDP + H2O = CMP + phosphate

210206, 210217, 756218, 210205, 210213, 210216, 210204, 654678, 656079, 757160

3.6.1.65

CDP + H2O = cytidine + diphosphate

CDP + H2O = ?

CDP + phosphate + acetyl-CoA = CTP + acetate + CoA

744820

6.5.1.1

ATP + CDP = P1-(5'-adenosyl),P3-(5'-cytidyl)triphosphate + diphosphate

722217

7.2.2.1

CDP + phosphate + Na+/out = CTP + H2O + Na+/in

654801

Product in Enzyme-catalyzed Reactions (270 results)

CDP-glucose + D-glucose 6-phosphate = trehalose 6-phosphate + CDP

2.4.1.186

2 entries

2.4.1.218

CDP-glucose + hydroquinone = CDP + hydroquinone-O-beta-D-glucopyranoside

2.4.1.242

CDP-glucose + (1,4-alpha-glucosyl)n = CDP + ?

2.4.1.245

CDP-alpha-D-glucose + D-glucose = alpha,alpha-trehalose + CDP

2.4.1.347

2 entries

2.4.1.35

CDP-glucose + p-nitrophenol = CDP + p-nitrophenyl beta-D-glucoside

2.4.1.382

2 entries

2.4.1.384

CDP-alpha-D-glucose + 3-hydroxyflavone = CDP + 3-hydroxyflavone 3-O-beta-D-glucoside

2.4.1.60

4 entries

2.4.1.80

CDP-glucose + N-acylsphingosine = CDP + D-glucosyl-N-acylsphingosine

489414

2.4.1.81

CDP-glucose + 4',7-dihydroxyflavone = CDP + 7-O-beta-D-glucosyl-4',7-dihydroxyflavone

2.7.1.1

CTP + D-glucose = CDP + D-glucose 6-phosphate

2.7.1.100

CTP + 5-methylthioribose = CDP + 5-methylthioribose 1-phosphate

640269

2.7.1.105

CTP + D-fructose 6-phosphate = CDP + beta-D-fructose 2,6-bisphosphate

2.7.1.108

3 entries

2.7.1.11

CTP + D-fructose 6-phosphate = CDP + D-fructose 1,6-bisphosphate

640421, 0, 640446, 640485, 640443, 640442, 640463, 640436, 640509, 640511

2.7.1.113

2 entries

2.7.1.12

CTP + D-gluconate = CDP + 6-phospho-D-gluconate

2.7.1.130

CTP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(beta-D-1,6-)-2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl beta-phosphate = CDP + 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate

640805

2.7.1.144

CTP + D-tagatose 6-phosphate = CDP + D-tagatose 1,6-bisphosphate

2.7.1.145

2 entries

2.7.1.15

CTP + D-ribose = CDP + D-ribose 5-phosphate

2.7.1.161

6 entries

2.7.1.164

CTP + L-seryl-tRNASec = CDP + O-phospho-L-seryl-tRNASec

2.7.1.165

3 entries

2.7.1.166

3-deoxy-alpha-D-manno-oct-2-ulopyranosyl-(2->6)-2-deoxy-2-[[(3R)-3-hydroxypentadecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose + CTP = 3-deoxy-4-O-phosphono-alpha-D-manno-oct-2-ulopyranosyl-(2->6)-2-deoxy-2-[[(3R)-3-hydroxypentadecanoyl]amino]-3-O-[(3R)-3-hydroxytetradecanoyl]-4-O-phosphono-beta-D-glucopyranosyl-(1->6)-2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-[[(3R)-3-hydroxytetradecanoyl]amino]-1-O-phosphono-alpha-D-glucopyranose + CDP

2.7.1.169

CTP + pantoate = CDP + 4-phosphopantoate

2.7.1.17

CTP + 1-deoxy-D-xylulose = CDP + 1-deoxy-D-xylulose 5-phosphate

CTP + phytol = CDP + phytyl phosphate

2.7.1.2

CTP + D-glucose = CDP + D-glucose 6-phosphate

2.7.1.20

CTP + adenosine = CDP + AMP

0, 641106, 641075, 641093, 641087, 641097

2.7.1.21

2 entries

2.7.1.213

cytidine + CTP = CMP + CDP

2.7.1.216

CTP + (2E,6E)-farnesol = CDP + (2E,6E)-farnesyl phosphate

2.7.1.23

2 entries

2.7.1.24

CTP + 3'-dephospho-CoA = CDP + CoA

2.7.1.25

CTP + adenosine 5-phosphosulfate = CDP + 3'-phosphoadenosine 5'-phosphosulfate

641213, 641211

2.7.1.26

CTP + riboflavin = CDP + riboflavin 5'-phosphate

2.7.1.29

CTP + dihydroxyacetone = CDP + dihydroxyacetone phosphate

641267, 641268

2.7.1.30

CTP + glycerol = CDP + glycerol 3-phosphate

2.7.1.32

CTP + choline = CDP + choline phosphate

CTP + D-fructose = CDP + D-fructose 6-phosphate

2.7.1.45

CTP + 2-dehydro-3-deoxy-D-gluconate = CDP + 6-phospho-2-dehydro-3-deoxy-D-gluconate

2.7.1.48

6 entries

2.7.1.49

CTP + 5-hydroxy-2-methylpyrimidine = CDP + 2-methyl-5-phosphopyrimidine

641657

2.7.1.50

CTP + 4-methyl-5-(2-hydroxyethyl)thiazole = CDP + 4-methyl-5-(2-phosphonooxyethyl)thiazole

2.7.1.52

CTP + 6-deoxy-L-galactose = CDP + 6-deoxy-L-galactose 1-phosphate

2.7.1.54

CTP + D-arabinose = CDP + D-arabinose 5-phosphate

2.7.1.56

CTP + D-fructose 1-phosphate = CDP + D-fructose 1,6-bisphosphate

640483, 641683, 0

2.7.1.59

CTP + N-acetyl-D-glucosamine = CDP + N-acetyl-D-glucosamine 6-phosphate

2.7.1.6

CTP + D-galactose = CDP + alpha-D-galactose 1-phosphate

2.7.1.63

2 entries

2.7.1.64

CTP + myo-inositol = CDP + myo-inositol 1-phosphate

636605

2.7.1.67

CTP + 1-phosphatidyl-1D-myo-inositol = CDP + 1-phosphatidyl-1D-myo-inositol 4-phosphate

2.7.1.7

5 entries

2.7.1.73

CTP + inosine = CDP + IMP

CTP + cellobiose = CDP + 6-phospho-beta-D-glucosyl-(1,4)-D-glucose

642059

2.7.1.86

CTP + NADH = CDP + NADPH

2.7.1.B19

CTP + geranylgeraniol = CDP + geranylgeranyl phosphate

2.7.1.B20

CTP + inosine = CDP + inosine 5'-phosphate

2.7.11.31

CTP + [hydroxymethylglutaryl-CoA reductase (NADPH)] = CDP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate

2.7.2.1

CTP + acetate = CDP + acetyl phosphate

642172, 0, 642176, 642189, 642184, 487537, 642179

2.7.2.14

CTP + isobutanoate = CDP + isobutanoyl phosphate

2.7.2.15

CTP + propanoate = CDP + propanoyl phosphate

2.7.2.18

CTP + isobutyrate = CDP + isobutyryl phosphate

2.7.2.3

4 entries

2.7.2.6

CTP + formate = CDP + formyl phosphate

2.7.4.10

CTP + AMP = CDP + ADP

642540, 0

2.7.4.14

39 entries

2.7.4.15

CTP + thiamine diphosphate = CDP + thiamine triphosphate

2.7.4.18

GMP + trans-farnesyl diphosphate = CDP + trans-farnesyl triphosphate

2.7.4.2

CTP + (R,S)-5-phosphomevalonate = CDP + (R,S)-5-diphosphomevalonate

CTP + (2E,6E)-farnesyl phosphate = CDP + (2E,6E)-farnesyl diphosphate

2.7.4.33

CMP + [phosphate]n = CDP + [phosphate]n-1

2.7.4.6

24 entries

2.7.4.9

CTP + dTMP = CDP + dTDP

2.7.4.B1

CTP + UMP = CDP + UDP

2.7.4.B7

CTP + (phosphate)n = CDP + (phosphate)n+1

2.7.7.103

CTP + phosphate = diphosphate + CDP

2.7.7.5

CDP + phosphate = phosphate + CDP

643453

2.7.7.53

P1(5'-adenosyl)-P4(5'-cytosyl) tetraphosphate + phosphate = CDP + ATP

643508

2.7.7.8

polycytidylic acid + phosphate = ? + CDP

2.7.8.44

2.7.8.45

CDP-glycerol + 4-O-[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = CDP + 4-O-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol

3.1.3.2

CTP + H2O = CDP + phosphate

3.1.3.5

5'-CTP + H2O = CDP + phosphate

3.1.3.8

CTP + H2O = CDP + phosphate

3.1.3.9

glucose + CTP = glucose 6-phosphate + CDP

3.1.4.16

CTP + H2O = CDP + phosphate

3.1.4.37

CTP + H2O = CDP + phosphate

3.6.1.15

2 entries

3.6.1.28

CTP + H2O = CDP + phosphate

CTP + H2O = CDP + phosphate

3.6.1.6

CTP + H2O = CDP + phosphate

3.6.1.9

CTP + H2O = CDP + phosphate

3.6.1.B17

CTP + H2O = CDP + phosphate

3.6.4.13

2 entries

3.6.4.B10

CTP + H2O = CDP + phosphate

3.6.4.B6

CTP + H2O = CDP + phosphate

4.1.1.33

CTP + 5-diphosphomevalonate = CDP + phosphate + isopentenyl diphosphate + CO2

0, 650496

4.1.1.49

CTP + oxaloacetate = CDP + phosphoenolpyruvate + CO2

5.6.1.2

CTP + H2O + a dynein associated with a microtubule at position n = CDP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)

247009, 247038, 247007

5.6.1.5

2 entries

5.6.1.6

CTP + H2O + closed Cl- channel = CDP + phosphate + open Cl- channel

CTP + H2O = CDP + phosphate

5.6.2.4

CTP + H2O = CDP + phosphate

6.2.1.13

CTP + acetate + CoA = CDP + phosphate + acetyl-CoA

6.3.1.14

CTP + diphthine + ammonia = CDP + phosphate + diphthamide

6.3.2.16

CTP + D-Ala + membrane-acceptor = CDP + phosphate + D-alanyl-membrane acceptor

6.3.2.17

CTP + 5,6,7,8-tetrahydropteroyl-Glu + Glu = CDP + phosphate + 5,6,7,8-tetrahydropteroyl-Glu2

6.3.2.3

CTP + gamma-Glu-L-Cys + Gly = CDP + phosphate + glutathione

6.3.2.5

CTP + (R)-4'-phosphopantothenate + L-Cys = (R)-4'-phosphopantothenoyl-L-cysteine + CDP + phosphate

0, 4412, 4406

CTP + imidazoleacetic acid + 5-phosphoribosyl diphosphate = CDP + phosphate + 5'-phosphoribosylimidazoleacetate + diphosphate

1618

6.6.1.2

CTP + hydrogenobyrinic acid a,c-diamide + Co2+ = CDP + phosphate + cob(II)yrinic acid a,c-diamide + H+

653078

7.1.2.2

CTP + H2O + H+/in = CDP + phosphate + H+/out

210238, 0

7.2.2.1

2 entries

7.2.2.10

CTP + H2O + Ca2+[side 1] = CDP + phosphate + Ca2+[side 2]

7.2.2.19

CTP + H2O + H+/in + K+/out = CDP + phosphate + H+/out + K+/in

246851, 0

7.3.2.1

CTP + H2O + phosphate/out = CDP + phosphate + phosphate/in

7.4.2.1

CTP + H2O + His/out = CDP + phosphate + His/in

246888

7.4.2.5

CTP + H2O + peptide/out = CDP + phosphate + peptide/in

7.6.2.11

spermidine/out + CTP + H2O = spermidine/in + CDP + phosphate

210316

7.6.2.2

2 entries

Enzyme Cofactor/Cosubstrate (4 results)

enhances activity

642004, 642021, 642022, 642006

2.7.4.1

706036

Activator in Enzyme-catalyzed Reactions (4 results)

allosteric activator

activation

stimulates

low activation, allosteric activator

288999

Inhibitor in Enzyme-catalyzed Reactions (105 results)

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1.1.1.342

competitive inhibitor with respect to CDP-3,6-dideoxy-D-glycero-D-glycero-4-hexulose and either an uncompetitive or a mixed type inhibitor with respect to NADPH

renal enzyme, 90% inhibition at 0.025 mM

637622

2.4.1.214

slight inhibition at 3-5 mM

1 mM, 10% inhibition

23% residual activity at 10 mg/ml

less effective than CTP

636800

2.4.3.4

less effective than CTP

745248

2.4.3.8

only partially relieved by excess Mg2+

1 mM, 33% inhibition

with ATP as substrate

636985

2.7.1.52

4.9 mM, 16% inhibition in presence of ATP

strong

50% inhibition at 0.4 mM, inhibition can be reversed by 2 mM Mg2+

94884

2.7.2.1

preincubation of acetate kinase with MgCl2, AlCl3, NaF, acetate, and either IDP, UDP, or CDP in place of ADP results in almost complete inhibition of activity

727839