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Ligand N6-methyladenine in DNA

Basic Ligand Information

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.11.51

N6-methyladenine in DNA + 2-oxoglutarate + O2 = adenine in DNA + formaldehyde + succinate + CO2

738025, 742207, 742235, 738971, 736883

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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.72

S-adenosyl-L-methionine + adenine in DNA = S-adenosyl-L-homocysteine + N6-methyladenine in DNA

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Substrate in Enzyme-catalyzed Reactions (1 result)

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EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.11.51

N6-methyladenine in DNA + 2-oxoglutarate + O2 = adenine in DNA + formaldehyde + succinate + CO2

738025, 742207, 742235, 736883, 738971

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Product in Enzyme-catalyzed Reactions (1 result)

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Show Product (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.72

S-adenosyl-L-methionine + adenine in DNA = S-adenosyl-L-homocysteine + N6-methyladenine in DNA

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Enzyme Kinetic Parameters

References & Links

Literature References (5)

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Show Reference (5 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

736883

27027282

DNA methylation on N-adenine in mammalian embryonic stem cells

2016

Wu, T.P.; Wang, T.; Seetin, M.G.; Lai, Y.; Zhu, S.; Lin, K.; Liu, Y.; Byrum, S.D.; Mackintosh, S.G.; Zhong, M.; Tackett, A.; Wang, G.; Hon, L.S.; Fang, G.; Swenberg, J.A.; Xiao, A.Z.

Nature

532

329-333

738025

25936838

N6-methyladenine DNA modification in Drosophila

2015

Zhang, G.; Huang, H.; Liu, D.; Cheng, Y.; Liu, X.; Zhang, W.; Yin, R.; Zhang, D.; Zhang, P.; Liu, J.; Li, C.; Liu, B.; Luo, Y.; Zhu, Y.; Zhang, N.; He, S.; He, C.; Wang, H.; Chen, D.

Cell

161

893-906

738971

-

Repair of methyl lesions in RNA by oxidative demethylation

2014

Ye, F.; Zhang, L.; Jin, L.; Zheng, M.; Jiang, H.; Luo, C.

MedChemComm

5

1797-1803

742207

27785372

DNA N6-methyladenine demethylase ALKBH1 enhances osteogenic differentiation of human MSCs

2016

Zhou, C.; Liu, Y.; Li, X.; Zou, J.; Zou, S.

Bone Res.

4

16033

742235

25936839

DNA methylation on N6-adenine in C. elegans

2015

Greer, E.L.; Blanco, M.A.; Gu, L.; Sendinc, E.; Liu, J.; Aristizabal-Corrales, D.; Hsu, C.H.; Aravind, L.; He, C.; Shi, Y.

Cell

161

868-878

Links to other databases for N6-methyladenine in DNA

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