Ligand N,N'-diacetylchitobiose

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Basic Ligand Information

Molecular Structure
Picture of N,N'-diacetylchitobiose (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C16H28N2O11
N,N'-diacetylchitobiose
CDOJPCSDOXYJJF-KSKNGZLJSA-N
Synonyms:
(GlcNAc)2, 2-(acetylamino)-4-O-[2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl]-2-deoxy-beta-D-glucopyranose, beta-1,4-N,N'-diacetyl-chitobiose, beta-D-GlcNAc-(1-4)-D-GlcNAc, beta-D-N,N'-diacetylchitobiose, beta-N,N'-diacetylchitobiose, D-N,N'-diacetylchito-bioside, di-acetylchitobiose, di-N-acetyl-beta-D-chitobiose, di-N-acetyl-chitobiose, di-N-acetylchitobiose, diacetylchitobiose, GlcNAc2, GlcNAcbeta(1-4)GlcNAcbeta, N,N'-diacetyl-beta-chitobiose, N,N'-diacetyl-beta-D-chitobiose, N,N'-diacetyl-chitobiose, N,N'-diacetylchiotobiose, N,N'-diacetylchitobiose[side 1], N,N-diacetylchitobiose, N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosamine, N-acetyl-beta-D-glucosaminyl-1,4-N-acetyl-beta-D-glucosamine, N-acetylchitobiose, N-acetylchitobioside, N-N'-diacetyl-chitobioside, [(1->4)-N-acetyl-beta-D-glucosaminyl]2

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N,N'-diacetylchitobiose + phosphate = N-acetyl-D-glucosamine + N-acetyl-alpha-D-glucosamine 1-phosphate
show the reaction diagram
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[protein]-Npi-phospho-L-histidine + N,N'-diacetylchitobiose[side 1] = [protein]-L-histidine + N,N'-diacetylchitobiose 6'-phosphate[side 2]
show the reaction diagram
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2-(acetylamino)-4-O-[2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl]-2-deoxy-beta-D-glucopyranose + H2O = 2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose + acetate
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (49 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (178 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
N,N-diacetylchitobiose + O2 = ?
show the reaction diagram
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UDP-galactose + N,N'-diacetylchitobiose = UDP + beta-D-Galp-(1->4)-beta-D-GlcpNAc-(1->4)-D-GlcpNAc
show the reaction diagram
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N,N'-diacetylchitobiose + phosphate = N-acetyl-D-glucosamine + N-acetyl-alpha-D-glucosamine 1-phosphate
show the reaction diagram
-
N,N'-diacetylchitobiose + alpha-D-mannose 1-phosphate = ? + phosphate
show the reaction diagram
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N,N'-diacetylchitobiose + alpha-D-mannose 1-phosphate = beta-1,4-D-mannopyranosyl-beta-1,4-N-acetyl-D-glucosaminyl-beta-1,4-N-acetyl-D-glucosamine + phosphate
show the reaction diagram
-
GDP-L-fucose + di-N-acetylchitobiose = GDP + ?
show the reaction diagram
-
UDPgalactose + di-acetylchitobiose = ?
show the reaction diagram
-
[protein]-Npi-phospho-L-histidine + N,N'-diacetylchitobiose[side 1] = [protein]-L-histidine + N,N'-diacetylchitobiose 6'-phosphate[side 2]
show the reaction diagram
-
N,N'-diacetyl-chitobiose + H2O = ?
show the reaction diagram
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lactose + N,N'-diacetylchitobiose = Gal-beta(1,4)-GlcNAc-beta(1,3)-Gal-beta(1,4)-Glc + H2O
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (815 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
[(1->4)-N-acetyl-beta-D-glucosaminyl]6 + ascorbate + O2 = [(1->4)-N-acetyl-beta-D-glucosaminyl]3-(1->4)-N-acetyl-2-deoxy-2-amino-D-glucono-1,5-lactone + [(1->4)-N-acetyl-beta-D-glucosaminyl]2 + dehydroascorbate + H2O
show the reaction diagram
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acetyl-CoA + chitobiose = CoA + N,N'-diacetylchitobiose + N-acetyl-D-glucosamine
show the reaction diagram
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UDP-GlcNAc + GlcNAc = UDP + N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosamine
show the reaction diagram
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-
N-acetyl-D-glucosamine + N-acetyl-alpha-D-glucosamine 1-phosphate = N,N'-diacetylchitobiose + phosphate
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates
-

Inhibitor in Enzyme-catalyzed Reactions (31 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

3D Structure of Enzyme-Ligand-Complex (PDB) (16 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (5 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
6.34
-
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
22
-
pH 5.5, 30°C, synthetic reaction
4.82
-
-
0.56
-
pH 4.0, 60°C
28.5
-
-

KM Value (13 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
18
-
-
49.9
-
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
27
-
pH 5.5, 30°C, synthetic reaction
1.59
-
-
33
-
-
10.8
-
pH 4.0, 60°C
31.8
-
pH 8.5, 75°C

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.025
-
pH 7.5, 37°C

References & Links