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Ligand 1-hexadecyl-glycero-3-phosphocholine

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.1.4

1-hexadecyl-2-acetyl-sn-glycerol-3-phosphocholine + H2O = 1-hexadecyl-sn-glycerol-3-phosphocholine + acetate

0

-

Substrate in Enzyme-catalyzed Reactions (3 results)

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Show Substrate (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.16.5

RS-3-(1-hexadecyloxy)-2-hydroxypropane-1-phosphocholine + RS-6-methyl-5,6,7,8-tetrahydropterin + O2 = ?

438651, 438653

-

2.3.1.148

1-Hexadecyl-2-lyso-glycerophosphocholine + phospholipid = ?

16278

-

3.1.4.41

1-O-hexadecylglycero-3-phosphocholine + H2O = choline + 1-O-hexadecylglycero-3-phosphate

652516

-

Product in Enzyme-catalyzed Reactions (8 results)

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Show Product (8 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.1.1.4

1-hexadecyl-2-acetyl-sn-glycerol-3-phosphocholine + H2O = 1-hexadecyl-sn-glycerol-3-phosphocholine + acetate

0

-

3.1.1.4

1-O-hexadecyl-2-arachidonyl-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-glycero-3-phosphocholine + arachidonic acid

133871, 133876

-

3.1.1.4

1-O-hexadecyl-2-[(cis)-9-octadecenoyl]-rac-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-rac-glycero-3-phosphocholine + cis-9-octadecenoate

649606

-

3.1.1.47

1-hexadecyl-2-butyryl-sn-glycero-3-phosphocholine + H2O = 1-hexadecyl-glycero-3-phosphocholine + butanoate

80948

-

3.1.1.47

1-hexadecyl-2-glutaryl-sn-glycero-3-phosphocholine + H2O = 1-hexadecyl-glycero-3-phosphocholine + glutarate

80946, 80951, 80955, 80948

-

3.1.1.47

1-hexadecyl-2-propionyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecyl-glycero-3-phosphocholine + propionate

80948

-

3.1.1.47

1-hexadecyl-2-succinyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecyl-glycero-3-phosphocholine + succinate

80946, 80955, 80948

-

3.1.1.47

1-hexadecyl-2-acetyl-sn-glycerol-3-phosphocholine + H2O = 1-hexadecyl-sn-glycerol-3-phosphocholine + acetate

80946, 80951, 80941, 80955, 80948

-

3.1.1.4

3 entries

3.1.1.47

5 entries

Inhibitor in Enzyme-catalyzed Reactions (1 result)

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Show Inhibitors (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.23

-

486619

-

Enzyme Kinetic Parameters

K_M Value (4 results)

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Show KM Value (4 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.14.16.5

0.173

-

with 6-methyl-5,6,7,8-tetrahydropterin as cofactor

438651

2.3.1.148

0.0015

-

-

16278

3.1.4.41

0.022

-

pH 7.4, 37°C

652516

3.1.4.41

0.044

-

pH 7.4, 37°C

652516

3.1.4.41

2 entries

K_i Value (1 result)

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Show KI Value (1 entry)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.3.1.23

0.08

-

-

486619

References & Links

Literature References (13)

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Show Reference (13 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

16278

1641397

The role of transacylases in the metabolism of arachidonate and platelet activating factor

1992

Snyder, F.; Lee, T.C.; Blank, M.L.

Prog. Lipid Res.

31

65-86

80941

7451433

A specific acetylhydrolase for 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (a hypotensive and platelet-activating lipid)

1981

Blank, M.L.; Lee, T.; Fitzgerald, V.; Snyder, F.

J. Biol. Chem.

256

175-178

80946

7822257

Purification and characterization of platelet-activating factor acetylhydrolase from peritoneal fluid obtained from guinea pigs after endotoxin shock

1994

Karasawa, K.; Yato, M.; Setaka, M.; Nojima, S.

J. Biochem.

116

374-379

80948

7673213

Purification and characterization of platelet-activating factor acetylhydrolase II from bovine liver cytosol

1995

Hattori, K.; Hattori, M.; Adachi, H.; Tsujimoto, M.; Arai, H.; Inoue, K.

J. Biol. Chem.

270

22308-22313

80951

7700381

Anti-inflammatory properties of a platelet-activating factor acetylhydrolase [see comments

1995

Tjoelker, L.W.; Wilder, C.; Eberhardt, C.; Stafforini, D.M.; Dietsch, G.; Schimpf, B.; Hooper, S.; Le Tong, H.; Cousens, L.S.; Zimmerman, G.A.; Yamada, Y.; McIntyre, T.M.; Prescott, S.M.; Gray, P.W.

Nature

374

549-553

80955

9612271

Secretory PAF-acetylhydrolase of the rat hepatobiliary system: characterization and partial purification

1998

Svetlov, S.; Howard, K.M.; Debuysere, M.S.; Olson, M.S.

Am. J. Physiol.

274

G891-G900

133871

9787801

Characterization of acidic Ca2+-independent phospholipase A2 of bovine lung

1998

Akiba, S.; Dodia, C.; Chen, X.; Fisher, A.B.

Comp. Biochem. Physiol. B

120

393-404

133876

8940072

Expression, purification and kinetic characterization of a recombinant 80-kDa intracellular calcium-independent phospholipase A2

1996

Wolf, M.J.; Gross, R.W.

J. Biol. Chem.

271

30879-30885

438651

8439399

A convenient spectrophotometric method for measuring the kinetic parameters of glyceryl-ether monooxygenase (EC 1.14.16.5)

1993

Kosar-Hashemi, B.; Armarego, W.L.F.

Biol. Chem. Hoppe-Seyler

374

9-25

438653

8074806

Glyceryl-ether monooxygenase (EC 1.14.16.5), part VI.: nature of the glyceryl-ether lipid substrates in aqueous buffer

1994

Taguchi, H.; Kosar-Hashemi, B.; Paal, B.; Yang, N.; Armarego, W.L.F.

Biol. Chem. Hoppe-Seyler

375

329-334

486619

429375

Detergent properties of water-soluble choline phosphatides. Selective solubilization of acyl-CoA:lysolecithin acyltransferase from thymocyte plasma membranes

1979

Weltzien, H.U.; Richter, G.; Ferber, E.

J. Biol. Chem.

254

3652-3657

649606

12387827

Characterization of Vibrio mimicus phospholipase A (PhlA) and cytotoxicity on fish cell

2002

Lee, J.H.; Ahn, S.H.; Kim, S.H.; Choi, Y.H.; Park, K.J.; Kong, I.S.

Biochem. Biophys. Res. Commun.

298

269-276

652516

14732720

Spider and bacterial sphingomyelinases D target cellular lysophosphatidic acid receptors by hydrolyzing lysophosphatidylcholine

2004

Van Meeteren, L.A.; Frederiks, F.; Giepmans, B.N.G.; Pedrosa, M.F.F.; Billington, S.J.; Jost, B.H.; Tambourgi, D.V.; Moolenaar, W.H.

J. Biol. Chem.

279

10833-10836

Links to other databases for 1-hexadecyl-glycero-3-phosphocholine

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Show Links (1 entry)

ChEBI

PubChem

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