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BRENDA support

Ligand Vancomycin

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Basic Ligand Information

Molecular Structure
Picture of Vancomycin (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C66H75ClN9O24
Vancomycin
MYPYJXKWCTUITO-FJCYQOGASA-N

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dTDP-beta-L-vancosamine + devancosaminyl-vancomycin = dTDP + vancomycin
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (18 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive
-
noncompetitive inhibition
-
31% of maximal activity
-
weak inhibition
-
vancomycin derivatives inhibit the glycosyl transferase activity
-
analysis of binding and dissociation constants with PDI and PDI domain deletion mutants
-
the antibiotic is primarily used against methicillin-resistant Staphylococcus, it recognizes the terminal D-Ala-D-Ala moiety of the peptide chain of peptidoglycan and inhibits the cross-linking of cell-wall peptidoglycan precursors, eventually causing bacterial cell lysis
-

Enzyme Kinetic Parameters

Ki Value (4 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
65.6
-
25°C, pH 8.0
15.11
-
at 25°C, pH 8.0

IC50 Value (8 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
46.39
-
25°C, pH 8.0
1.18
-
25°C, pH 8.5
4.83
-
at 25°C, pH 8.0
0.004
-
pH and temperature not specified in the publication

References & Links

Links to other databases for Vancomycin

ChEBI
PubChem
-
PubChem