Ligand pyrroloquinoline quinone

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Basic Ligand Information

Molecular Structure
Picture of pyrroloquinoline quinone (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C14H6N2O8
pyrroloquinoline quinone
MMXZSJMASHPLLR-UHFFFAOYSA-N
Synonyms:
2,7,9-tricarboxypyrroloquinoline quinone, 4,5-Dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid, 4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate, 4,5-dioxo-3a,4,5,6,7,8,9,9b-octahydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate, 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate, PQQ, pyrroliquinoline quinone, pyrrolo-quinoline quinone, pyrroloquinoline-quinone, pyrrolquinoline quinone, vitamin PQQ
Pathway Source
Pathways


Show all pahtways known for Show all BRENDA pathways known for pyrroloquinoline quinone

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (11 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
quinate + pyrroloquinoline-quinone = 3-dehydroquinate + reduced pyrroloquinoline-quinone
show the reaction diagram
-
(S)-2-hydroxyglutarate + pyrroloquinoline quinone = 2-oxoglutarate + pyrroloquinoline quinol
show the reaction diagram
-
lupanine + pyrroloquinoline quinone + H2O = 17-hydroxylupanine + pyrroloquinoline quinol
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (116 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
pyrroloquinoline quinone + O2 = ?
show the reaction diagram
-
quinate + pyrroloquinoline-quinone = 3-dehydroquinate + reduced pyrroloquinoline-quinone
show the reaction diagram
-
(S)-2-hydroxyglutarate + pyrroloquinoline quinone = 2-oxoglutarate + pyrroloquinoline quinol
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Enzyme Cofactor/Cosubstrate (519 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
one pyrroquinoline covalently bound to one molecule, additional two-electron redox center
-
only pyrroloquinoline quinone is effective as electron acceptor, no activity with FAD, FMN and NAD(P)+
-
dependent on
-
dependent on
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quinohemoprotein. Enzyme has two active centers: cytochrome c and pyrroloquinoline quinone
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pyrroloquinoline quinone-to-subunit stochiometry of approximately 1:1, 3.6 mol of pyrroloquinoline quinone per mol of enzyme
-
enzyme may contain pyrroloquinoline-quinione as prosthetic group
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covalently bound
-

Activator in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
as prosthetic group
-
PQQ
-

Inhibitor in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

3D Structure of Enzyme-Ligand-Complex (PDB) (300 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

KM Value (19 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

References & Links

Links to other databases for pyrroloquinoline quinone

ChEBI
PubChem
ChEBI
PubChem