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Ligand dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C1 6 H2 7 N3 O1 2 P2
dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose
QBCDCCNQCPTNSU-GSZZWUTPSA-N
dTDP-4-amino-2,3,4,6-tetradeoxy-D-glucose
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)
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S-adenosyl-L-methionine + dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose = S-adenosyl-L-homocysteine + dTDP-alpha-D-forosamine
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dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2-oxoglutarate = dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate
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Substrate in Enzyme-catalyzed Reactions (2 results)
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S-adenosyl-L-methionine + dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose = S-adenosyl-L-homocysteine + dTDP-alpha-D-forosamine
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dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose + 2-oxoglutarate = dTDP-4-dehydro-2,3,6-trideoxy-alpha-D-hexopyranose + L-glutamate
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Enzyme Kinetic Parameters
References & Links Literature References (2)
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In vitro characterization of the enzymes involved in TDP-D-forosamine biosynthesis in the spinosyn pathway of Saccharopolyspora spinosa
2008
Hong, L.; Zhao, Z.; Melancon III, C.; Zhang, H.; Liu, H.
J. Am. Chem. Soc.
130
4954-4967
Characterization of protein encoded by spnR from the spinosyn gene cluster of Saccharopolyspora spinosa: mechanistic implications for forosamine biosynthesis
2005
Zhao, Z.; Hong, L.; Liu, H.W.
J. Am. Chem. Soc.
127
7692-7693
Links to other databases for dTDP-4-amino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranose