Ligand nicotinamide hypoxanthine dinucleotide

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Basic Ligand Information

Molecular Structure
Picture of nicotinamide hypoxanthine dinucleotide (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C21H26N6O15P2
nicotinamide hypoxanthine dinucleotide
DGVSIBCCYUVRNA-NNYOXOHSSA-O
Synonyms:
3-carbamoyl-1-((2R,3R,4S,5R)-5-((((((((2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)pyridin-1-ium, NHD, Nicotinamide-hypoxanthine-dinucleotide, nicotinamide-hypoxanthine dinucleotide, nicotinamide purin-6-ol-dinucleotide

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ITP + nicotinamide ribonucleotide = nicotinamide hypoxanthine dinucleotide + diphosphate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-mannitol 1-phosphate + nicotinamide hypoxanthine dinucleotide = D-fructose 6-phosphate + ?
show the reaction diagram
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UDP-glucose + nicotinamide hypoxanthine dinucleotide + H2O = UDP-glucuronate + ?
show the reaction diagram
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(S)-lactate + nicotinamide hypoxanthine dinucleotide = pyruvate + reduced nicotinamide hypoxanthine dinucleotide
show the reaction diagram
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L-quinate + nicotinamide hypoxanthine dinucleotide = 3-dehydroquinate + ?
show the reaction diagram
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formaldehyde + glutathione + nicotinamide-hypoxanthine dinucleotide = S-formylglutathione + ?
show the reaction diagram
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nicotinamide hypoxanthine dinucleotide + L-malate = ?
show the reaction diagram
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lipoamide + nicotinamide hypoxanthine dinucleotide = dihydrolipoamide + ?
show the reaction diagram
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nicotinamide hypoxanthine dinucleotide + [dinitrogen reductase] = ?
show the reaction diagram
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nicotinamide hypoxanthine dinucleotide + H2O = ?
show the reaction diagram
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nicotinamide-hypoxanthine dinucleotide + H2O = ?
show the reaction diagram
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nicotinamide hypoxanthine dinucleotide + H2O = NMN + hypoxanthine monophosphate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
NAD+ + H2O = nicotinamide-hypoxanthine dinucleotide + NH3
show the reaction diagram
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Enzyme Cofactor/Cosubstrate (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
alternative coenzyme
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1.3fold higher activity than with NAD+
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can substitute for beta-NAD+
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i.e. deamino-NAD+, 36% of the activity with NAD+ when cholic acid is utilized as substrate
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
can replace NAD+
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Inhibitor in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
1 mM, 24% inhibition
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addition of 1 mM nicotinamide hypoxanthine dinucleotide, inhibition 61.4%
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0.02 mM, 96% residual activity in presence of 0.05 mM NAD, pH 7.4
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3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (4 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (9 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.48
-
pH 10, cosubstrate (-)-quinate
0.0352
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0.25
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0.063
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2.6
-
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1.44
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0.015
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References & Links

Links to other databases for nicotinamide hypoxanthine dinucleotide

ChEBI
PubChem
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PubChem