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Ligand beta,gamma-methylene-GTP

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (6 results)

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Show Substrate (6 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.5.4.16

beta,gamma-methyleneguanosine 5'-triphosphate + H2O = dihydroneopterin 2',3'-cyclic phosphate + ?

685163

-

3.5.4.16

beta-gamma-methyleneguanosine 5'-triphosphate + H2O = beta-gamma-methylene-7,8-dihydroneopterin 3'-triphosphate + formate

209547

-

3.5.4.16

2 entries

3.5.4.29

beta,gamma-methylene-GTP + H2O = 2-amino-5-formylamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + methyl phosphonate

639020

-

3.5.4.39

beta,gamma-methylene-GTP + H2O = ?

685163

-

4.6.1.2

guanosine 5'-beta,gamma-methylene triphosphate = ?

680671

-

4.6.1.2

guanyl-(beta,gamma-methylene)-diphosphate = ?

34840

-

4.6.1.2

2 entries

Activator in Enzyme-catalyzed Reactions (3 results)

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Show Activating Compound (3 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

3.6.5.3

non-hydrolyzable or slowly hydrolyzable GTP analogues such as GMP-PCP and GMP-PNP, able to stall elongation factor on the ribosome, increase the efficiency of the reverse translocation reaction

757215

-

4.1.1.17

stimulates

4021

-

4.6.1.1

activation

34782

-

Inhibitor in Enzyme-catalyzed Reactions (9 results)

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Show Inhibitors (9 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

3.1.3.6

-

750491

-

3.5.4.29

0.6 mM, 34% inhibition of GTP cyclohydrolase activity

639020

-

3.6.5.5

-

644186

3w6o, 3D-view

3.6.5.5

-

644186

5wp9, 3D-view

3.6.5.5

-

644186

6dlu, 3D-view

3.6.5.5

-

644186

7ax3, 3D-view

3.6.5.5

4 entries

6.3.2.31

5 mM, 56% inhibition

696202

-

6.3.2.34

5 mM, 56% inhibition

696202

-

6.3.4.4

-

1537

1hop, 3D-view

3D Structure of Enzyme-Ligand-Complex (PDB) (274 results)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (274 entries)

EC NUMBER

ENZYME 3D STRUCTURE

2.7.1.33

3af3, 3D-view

2.7.1.33

3af4, 3D-view

2.7.1.33

3af3, 3D-view

2.7.1.33

3af4, 3D-view

2.7.1.33

3af3, 3D-view

2.7.1.33

3af4, 3D-view

2.7.1.33

3af3, 3D-view

2.7.1.33

3af4, 3D-view

2.7.1.33

3af3, 3D-view

2.7.1.33

3af4, 3D-view

2.7.1.33

3af3, 3D-view

2.7.1.33

3af4, 3D-view

2.7.1.33

3af3, 3D-view

2.7.1.33

3af4, 3D-view

2.7.1.33

3af3, 3D-view

2.7.1.33

3af4, 3D-view

2.7.1.33

3af3, 3D-view

2.7.1.33

3af4, 3D-view

2.7.1.33

3af3, 3D-view

2.7.1.33

3af4, 3D-view

2.7.1.33

3af3, 3D-view

2.7.1.33

3af4, 3D-view

2.7.1.33

22 entries

2.7.11.1

2ov2, 3D-view

2.7.11.13

2rmk, 3D-view

2.7.4.3

6f7u, 3D-view

3.1.1.29

6vlz, 3D-view

3.1.1.29

6vmi, 3D-view

3.1.1.29

7a5g, 3D-view

3.1.1.29

7a5k, 3D-view

3.1.1.29

7l20, 3D-view

3.1.1.29

7pd3, 3D-view

3.1.1.29

6vlz, 3D-view

3.1.1.29

6vmi, 3D-view

3.1.1.29

7a5g, 3D-view

3.1.1.29

7a5k, 3D-view

3.1.1.29

7l20, 3D-view

3.1.1.29

7pd3, 3D-view

3.1.1.29

6vlz, 3D-view

3.1.1.29

6vmi, 3D-view

3.1.1.29

7a5g, 3D-view

3.1.1.29

7a5k, 3D-view

3.1.1.29

7l20, 3D-view

3.1.1.29

7pd3, 3D-view

3.1.1.29

6vlz, 3D-view

3.1.1.29

6vmi, 3D-view

3.1.1.29

7a5g, 3D-view

3.1.1.29

7a5k, 3D-view

3.1.1.29

7l20, 3D-view

3.1.1.29

7pd3, 3D-view

3.1.1.29

6vlz, 3D-view

3.1.1.29

6vmi, 3D-view

3.1.1.29

7a5g, 3D-view

3.1.1.29

7a5k, 3D-view

3.1.1.29

7l20, 3D-view

3.1.1.29

7pd3, 3D-view

3.1.1.29

6vlz, 3D-view

3.1.1.29

6vmi, 3D-view

3.1.1.29

7a5g, 3D-view

3.1.1.29

7a5k, 3D-view

3.1.1.29

7l20, 3D-view

3.1.1.29

7pd3, 3D-view

3.1.1.29

6vlz, 3D-view

3.1.1.29

6vmi, 3D-view

3.1.1.29

7a5g, 3D-view

3.1.1.29

7a5k, 3D-view

3.1.1.29

7l20, 3D-view

3.1.1.29

7pd3, 3D-view

3.1.1.29

6vlz, 3D-view

3.1.1.29

6vmi, 3D-view

3.1.1.29

7a5g, 3D-view

3.1.1.29

7a5k, 3D-view

3.1.1.29

7l20, 3D-view

3.1.1.29

7pd3, 3D-view

3.1.1.29

6vlz, 3D-view

3.1.1.29

6vmi, 3D-view

3.1.1.29

7a5g, 3D-view

3.1.1.29

7a5k, 3D-view

3.1.1.29

7l20, 3D-view

3.1.1.29

7pd3, 3D-view

3.1.1.29

6vlz, 3D-view

3.1.1.29

6vmi, 3D-view

3.1.1.29

7a5g, 3D-view

3.1.1.29

7a5k, 3D-view

3.1.1.29

7l20, 3D-view

3.1.1.29

7pd3, 3D-view

3.1.1.29

6vlz, 3D-view

3.1.1.29

6vmi, 3D-view

3.1.1.29

7a5g, 3D-view

3.1.1.29

7a5k, 3D-view

3.1.1.29

7l20, 3D-view

3.1.1.29

7pd3, 3D-view

3.1.1.29

66 entries

3.1.3.16

7sd0, 3D-view

3.6.1.48

2j7k, 3D-view

3.6.1.55

4jzu, 3D-view

3.6.1.55

4jzv, 3D-view

3.6.1.55

4jzu, 3D-view

3.6.1.55

4jzv, 3D-view

3.6.1.55

4jzu, 3D-view

3.6.1.55

4jzv, 3D-view

3.6.1.55

4jzu, 3D-view

3.6.1.55

4jzv, 3D-view

3.6.1.55

4jzu, 3D-view

3.6.1.55

4jzv, 3D-view

3.6.1.55

4jzu, 3D-view

3.6.1.55

4jzv, 3D-view

3.6.1.55

4jzu, 3D-view

3.6.1.55

4jzv, 3D-view

3.6.1.55

4jzu, 3D-view

3.6.1.55

4jzv, 3D-view

3.6.1.55

4jzu, 3D-view

3.6.1.55

4jzv, 3D-view

3.6.1.55

4jzu, 3D-view

3.6.1.55

4jzv, 3D-view

3.6.1.55

4jzu, 3D-view

3.6.1.55

4jzv, 3D-view

3.6.5.2

4cym, 3D-view

3.6.5.2

7aca, 3D-view

3.6.5.2

7acf, 3D-view

3.6.5.2

7ach, 3D-view

3.6.5.2

7lz5, 3D-view

3.6.5.2

7rov, 3D-view

3.6.5.2

7sd0, 3D-view

3.6.5.2

7t47, 3D-view

3.6.5.2

4cym, 3D-view

3.6.5.2

7aca, 3D-view

3.6.5.2

7acf, 3D-view

3.6.5.2

7ach, 3D-view

3.6.5.2

7lz5, 3D-view

3.6.5.2

7rov, 3D-view

3.6.5.2

7sd0, 3D-view

3.6.5.2

7t47, 3D-view

3.6.5.2

4cym, 3D-view

3.6.5.2

7aca, 3D-view

3.6.5.2

7acf, 3D-view

3.6.5.2

7ach, 3D-view

3.6.5.2

7lz5, 3D-view

3.6.5.2

7rov, 3D-view

3.6.5.2

7sd0, 3D-view

3.6.5.2

7t47, 3D-view

3.6.5.2

4cym, 3D-view

3.6.5.2

7aca, 3D-view

3.6.5.2

7acf, 3D-view

3.6.5.2

7ach, 3D-view

3.6.5.2

7lz5, 3D-view

3.6.5.2

7rov, 3D-view

3.6.5.2

7sd0, 3D-view

3.6.5.2

7t47, 3D-view

3.6.5.2

4cym, 3D-view

3.6.5.2

7aca, 3D-view

3.6.5.2

7acf, 3D-view

3.6.5.2

7ach, 3D-view

3.6.5.2

7lz5, 3D-view

3.6.5.2

7rov, 3D-view

3.6.5.2

7sd0, 3D-view

3.6.5.2

7t47, 3D-view

3.6.5.2

4cym, 3D-view

3.6.5.2

7aca, 3D-view

3.6.5.2

7acf, 3D-view

3.6.5.2

7ach, 3D-view

3.6.5.2

7lz5, 3D-view

3.6.5.2

7rov, 3D-view

3.6.5.2

7sd0, 3D-view

3.6.5.2

7t47, 3D-view

3.6.5.2

4cym, 3D-view

3.6.5.2

7aca, 3D-view

3.6.5.2

7acf, 3D-view

3.6.5.2

7ach, 3D-view

3.6.5.2

7lz5, 3D-view

3.6.5.2

7rov, 3D-view

3.6.5.2

7sd0, 3D-view

3.6.5.2

7t47, 3D-view

3.6.5.2

4cym, 3D-view

3.6.5.2

7aca, 3D-view

3.6.5.2

7acf, 3D-view

3.6.5.2

7ach, 3D-view

3.6.5.2

7lz5, 3D-view

3.6.5.2

7rov, 3D-view

3.6.5.2

7sd0, 3D-view

3.6.5.2

7t47, 3D-view

3.6.5.2

4cym, 3D-view

3.6.5.2

7aca, 3D-view

3.6.5.2

7acf, 3D-view

3.6.5.2

7ach, 3D-view

3.6.5.2

7lz5, 3D-view

3.6.5.2

7rov, 3D-view

3.6.5.2

7sd0, 3D-view

3.6.5.2

7t47, 3D-view

3.6.5.2

4cym, 3D-view

3.6.5.2

7aca, 3D-view

3.6.5.2

7acf, 3D-view

3.6.5.2

7ach, 3D-view

3.6.5.2

7lz5, 3D-view

3.6.5.2

7rov, 3D-view

3.6.5.2

7sd0, 3D-view

3.6.5.2

7t47, 3D-view

3.6.5.2

4cym, 3D-view

3.6.5.2

7aca, 3D-view

3.6.5.2

7acf, 3D-view

3.6.5.2

7ach, 3D-view

3.6.5.2

7lz5, 3D-view

3.6.5.2

7rov, 3D-view

3.6.5.2

7sd0, 3D-view

3.6.5.2

7t47, 3D-view

3.6.1.55

22 entries

3.6.5.2

88 entries

3.6.5.4

2xxa, 3D-view

3.6.5.5

3w6o, 3D-view

3.6.5.5

5wp9, 3D-view

3.6.5.5

6dlu, 3D-view

3.6.5.5

7ax3, 3D-view

3.6.5.5

3w6o, 3D-view

3.6.5.5

5wp9, 3D-view

3.6.5.5

6dlu, 3D-view

3.6.5.5

7ax3, 3D-view

3.6.5.5

3w6o, 3D-view

3.6.5.5

5wp9, 3D-view

3.6.5.5

6dlu, 3D-view

3.6.5.5

7ax3, 3D-view

3.6.5.5

3w6o, 3D-view

3.6.5.5

5wp9, 3D-view

3.6.5.5

6dlu, 3D-view

3.6.5.5

7ax3, 3D-view

3.6.5.5

3w6o, 3D-view

3.6.5.5

5wp9, 3D-view

3.6.5.5

6dlu, 3D-view

3.6.5.5

7ax3, 3D-view

3.6.5.5

3w6o, 3D-view

3.6.5.5

5wp9, 3D-view

3.6.5.5

6dlu, 3D-view

3.6.5.5

7ax3, 3D-view

3.6.5.5

3w6o, 3D-view

3.6.5.5

5wp9, 3D-view

3.6.5.5

6dlu, 3D-view

3.6.5.5

7ax3, 3D-view

3.6.5.5

3w6o, 3D-view

3.6.5.5

5wp9, 3D-view

3.6.5.5

6dlu, 3D-view

3.6.5.5

7ax3, 3D-view

3.6.5.5

3w6o, 3D-view

3.6.5.5

5wp9, 3D-view

3.6.5.5

6dlu, 3D-view

3.6.5.5

7ax3, 3D-view

3.6.5.5

3w6o, 3D-view

3.6.5.5

5wp9, 3D-view

3.6.5.5

6dlu, 3D-view

3.6.5.5

7ax3, 3D-view

3.6.5.5

3w6o, 3D-view

3.6.5.5

5wp9, 3D-view

3.6.5.5

6dlu, 3D-view

3.6.5.5

7ax3, 3D-view

4.1.1.32

1khb, 3D-view

4.1.1.32

1khe, 3D-view

4.1.1.32

1khb, 3D-view

4.1.1.32

1khe, 3D-view

4.1.1.32

1khb, 3D-view

4.1.1.32

1khe, 3D-view

4.1.1.32

1khb, 3D-view

4.1.1.32

1khe, 3D-view

4.1.1.32

1khb, 3D-view

4.1.1.32

1khe, 3D-view

4.1.1.32

1khb, 3D-view

4.1.1.32

1khe, 3D-view

4.1.1.32

1khb, 3D-view

4.1.1.32

1khe, 3D-view

4.1.1.32

1khb, 3D-view

4.1.1.32

1khe, 3D-view

4.1.1.32

1khb, 3D-view

4.1.1.32

1khe, 3D-view

4.1.1.32

1khb, 3D-view

4.1.1.32

1khe, 3D-view

4.1.1.32

1khb, 3D-view

4.1.1.32

1khe, 3D-view

3.6.5.5

44 entries

4.1.1.32

22 entries

4.2.99.18

7nwh, 3D-view

6.2.1.4

7jj0, 3D-view

6.2.1.5

7jj0, 3D-view

6.3.4.4

1hop, 3D-view

Enzyme Kinetic Parameters

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

4.6.1.2

0.37

-

-

34840

K_i Value (1 result)

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Show KI Value (1 entry)

EC NUMBER

KI VALUE [MM]

KI VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

3.1.3.6

0.01732

-

at pH 7.4 and 25°C

750491

References & Links

Literature References (12)

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Show Reference (12 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

1537

6347525

Regulation, genetics, and properties of adenylosuccinate synthetase

1983

Stayton, M.M.; Rudolph, F.B.; Fromm, H.J.

Curr. Top. Cell. Regul.

22

103-141

4021

6824682

Ornithine decarboxylase activity from an extremely thermophilic bacterium, Clostridium thermohydrosulfuricum

1983

Paulin, L.; Poesoe, H.

Biochim. Biophys. Acta

742

197-205

34782

206324

Some comparative properties and localization of porcine jejunal adenylate cyclase

1978

Forsyth, G.W.; Hamilton, D.L.; Goertz, K.E.; Oliphant, L.W.

Can. J. Biochem.

56

280-286

34840

28767

Purification and properties of guanylate cyclase from the synaptosomal soluble fraction of rat brain

1978

Nakane, M.; Deguchi, T.

Biochim. Biophys. Acta

525

275-285

209547

6385856

Formation of beta,gamma-methylene-7,8-dihydroneopterin 3-triphosphate from beta,gamma-methyleneguanosine 5-triphosphate by GTP cyclohydrolase I of Escherichia coli

1984

Ferre, J.; Jacobson, K.B.

Arch. Biochem. Biophys.

233

475-480

639020

12475257

A member of a new class of GTP cyclohydrolases produces formylaminopyrimidine nucleotide monophosphates

2002

Graham, D.E.; Xu, H.; White, R.H.

Biochemistry

41

15074-15084

644186

1311055

Dynamin is a GTPase stimulated to high levels of activity by microtubules

1992

Shpetner, H.S.; Vallee, R.B.

Nature

355

733-735

680671

16754683

Functional characterization of two nucleotide-binding sites in soluble guanylate cyclase

2006

Yazawa, S.; Tsuchiya, H.; Hori, H.; Makino, R.

J. Biol. Chem.

281

21763-21770

685163

17497938

Characterization of an Fe(2+)-dependent archaeal-specific GTP cyclohydrolase, MptA, from Methanocaldococcus jannaschii

2007

Grochowski, L.L.; Xu, H.; Leung, K.; White, R.H.

Biochemistry

46

6658-6667

696202

12911320

CofE catalyzes the addition of two glutamates to F420-0 in F420 coenzyme biosynthesis in Methanococcus jannaschii

2003

Li, H.; Graupner, M.; Xu, H.; White, R.H.

Biochemistry

42

9771-9778

750491

27531705

Inhibitory effects promoted by 5'-nucleotides on the ecto-3'-nucleotidase activity of Leishmania amazonensis

2016

Freitas-Mesquita, A.L.; Gomes, M.T.; Vieira, D.P.; Paes-Vieira, L.; Nascimento, M.T.; Lopes, A.H.; Meyer-Fernandes, J.R.

Exp. Parasitol.

169

111-118

757215

29453282

Eukaryotic translation elongation factor 2 (eEF2) catalyzes reverse translocation of the eukaryotic ribosome

2018

Susorov, D.; Zakharov, N.; Shuvalova, E.; Ivanov, A.; Egorova, T.; Shuvalov, A.; Shatsky, I.N.; Alkalaeva, E.

J. Biol. Chem.

293

5220-5229

Links to other databases for beta,gamma-methylene-GTP

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Show Links (1 entry)

ChEBI

PubChem