Ligand Na2S

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Basic Ligand Information

Molecular Structure
Picture of Na2S (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
Na2S
Na2S
GRVFOGOEDUUMBP-UHFFFAOYSA-N
Synonyms:
Sodium sulfide

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
show the reaction diagram
O-succinyl-L-homoserine + sodium sulfide = L-homocysteine + sodium succinate
-
show the reaction diagram
dethiobiotin + Na2S = biotin
-

Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
LITERATURE
REACTION DIAGRAM
REACTION
ENZYME 3D STRUCTURE
-
show the reaction diagram
L-cysteine + NaCN = L-3-cyanoalanin + Na2S
-

Activator in Enzyme-catalyzed Reactions (1 result)

COMMENTARY
EC NUMBER
LITERATURE
ENZYME 3D STRUCTURE
activates, (Z)-phenylacetaldoxime dehydration, 1 mM, 8.35fold
-

Inhibitor in Enzyme-catalyzed Reactions (20 results)

COMMENTARY
EC NUMBER
LITERATURE
ENZYME 3D STRUCTURE
competitive vs. beta-hydroxybutyrate
-
the enzyme activity is inhibited by up to 29-32% using 2 and 5 mM Na2S as H2S donor
-
around 23% inhibition with 1 to 5 mM Na2S
-
2 mM concentration 76% inhibition, 20 mM concentration 94% concentration
-
partially purified 6-HDH, 90% loss of activity
-
temporarily inhibition; together with sulfide no inhibition
-
50% inhibition at 0.3 mM
-
50% inhibition at 1.3 mM
-
60% loss of activity at 10 mM
-
10 mM, 92% inhibition
-

Metals and Ions (3 results)

COMMENTARY
EC NUMBER
LITERATURE
ENZYME 3D STRUCTURE
enhances activity 3-4fold at 1 mM
-
required for formation of mixed [Fe-S] cluster state
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

COMMENTARY
EC NUMBER
LITERATURE
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
30°C, pH 8.0
1.5
-

KM Value (6 results)

COMMENTARY
EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
LITERATURE
30°C, pH 8.0
0.04
-
pH 7.5

Ki Value (1 result)

COMMENTARY
EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
LITERATURE
-
5
-

References & Links

Links to other databases for Na2S

ChEBI
PubChem
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PubChem