Ligand L-homoarginine

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Basic Ligand Information

Molecular Structure
Picture of L-homoarginine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C7H16N4O2
L-homoarginine
QUOGESRFPZDMMT-YFKPBYRVSA-N
Synonyms:
hArg, L-2-amino-6-guanidinohexanoate, L-2-amino-6-guanidohexanoate, L-hArg

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-ornithine + L-homoarginine = L-arginine + L-lysine
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-arginine + L-lysine = L-ornithine + L-homoarginine
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (14 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-homoarginine + O2 = ?
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L-homoarginine + NADPH + O2 = ?
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L-homoarginine + H2O + O2 = 2-oxohomoarginine + NH3 + H2O2
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L-ornithine + L-homoarginine = L-arginine + L-lysine
show the reaction diagram
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succinyl-CoA + L-homoarginine = CoA + N2-succinyl-L-homoarginine
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ATP + L-homoarginine = ADP + Nomega-phospho-L-homoarginine
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L-homoarginine + H2O = L-2,6-diaminohexanoate + urea
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L-homoarginine + H2O = ? + NH3
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L-homoarginine + H2O = (2S)-2-amino-6-[(aminocarbonyl)amino]hexanoic acid + NH3
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L-Homoarginine = L-Homoarginine
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L-Homoarginine = D-Homoarginine
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ATP + L-homoarginine + tRNACCCG = AMP + diphosphate + L-homoarginyl-tRNACCCG
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Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-arginine + L-lysine = L-ornithine + L-homoarginine
show the reaction diagram
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hArg-7-amido-4-methylcoumarin + H2O = hArg + 7-amino-4-methylcoumarin
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L-hArg-7-amido-4-carbamoylmethylcoumarin + H2O = L-hArg + 7-amino-4-carbamoylmethylcoumarin
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
5 mM, activation of alkaline phosphatase grown in high phosphate medium to 186% of the control value, alkaline phosphatase grown in low phosphate medium is activated to 166% of control
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Inhibitor in Enzyme-catalyzed Reactions (16 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
5fold higher concentration than L-Arg, 33% inhibition
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3D Structure of Enzyme-Ligand-Complex (PDB) (21 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
13.85
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pH 8.0, 30°C

KM Value (2 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
7.05
-
pH 8.0, 30°C
4.7
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Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
7
-
pH 7.3, 30°C
1.53
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pH 7.5, 37°C

References & Links

Links to other databases for L-homoarginine

ChEBI
PubChem
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PubChem