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Ligand ergosta-5,7,22,24(241)-tetraen-3beta-ol

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Natural Substrate (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.3.1.71

ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H+ = ergosta-5,7,22-trien-3beta-ol + NADP+

390846, 390847, 390848, 390845

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1.3.1.71

ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H+ = ergosterol + NADP+

745462

-

1.3.1.71

2 entries

Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.3.1.71

ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H+ = ergosta-5,7,22-trien-3beta-ol + NADP+

390846, 390847, 390848, 684606, 390845

-

1.3.1.71

ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H+ = ergosterol + NADP+

745462

-

1.3.1.71

2 entries

Product in Enzyme-catalyzed Reactions (3 results)

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Show Product (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.19.20

5alpha-ergost-7,24(241)-dien-3beta-ol + O2 + ferrocytochrome b5 = ergosta-5,7,24(241)-trien-3beta-ol + H2O2 + ferricytochrome b5

390937

-

1.14.19.20

5alpha-ergosta-7,24-dien-3beta-ol + ferrocytochrome b5 + O2 + H+ = ergosta-5,7,24-trien-3beta-ol + ferricytochrome b5 + H2O

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1.14.19.20

2 entries

1.3.1.71

ergosta-5,7,22-trien-3beta-ol + NADP+ = ergosta-5,7,22,24(241)-tetraen-3beta-ol + NADPH + H+

390846, 390847, 390848, 390845

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Enzyme Kinetic Parameters

K_M Value (1 result)

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Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.3.1.71

0.0108

-

-

390845

References & Links

Literature References (7)

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Show Reference (7 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

390845

14922

Sterol 24(28) methylene reductase in Saccharomyces cerevisiae

1977

Neal, W.D.; Parks, L.W.

J. Bacteriol.

129

1375-1378

390846

352402

Azasterol inhibitors in yeast. Inhibition of the 24-methylene sterol DELTA24(28)-reductase and DELTA24-sterol methyltransferase of Saccharomyces cerevisiae by 23-azacholesterol

1978

Pierce, H.D., Jr.; Pierce, A.M.; Srinivasan, R.; Unrau, A.M.; Oehlschlager, A.C.

Biochim. Biophys. Acta

529

429-437

390847

373868

Azasterol inhibitors in yeast. Inhibition of the DELTA24-sterol methyltransferase and the 24-methylene sterol DELTA24(28)-reductase in sterol mutants of Saccharomyces cerevisiae

1979

Pierce, A.M.; Unrau, A.M.; Oehlschlager, A.C.; Woods, R.A.

Can. J. Biochem.

57

201-208

390848

10722850

Biochemical characterization and subcellular localization of the sterol C-24(28) reductase, Erg4p, from the yeast Saccharomyces cerevisiae

2000

Zweytick, D.; Hrastnik, C.; Kohlwein, S.D.; Daum, G.

FEBS Lett.

470

83-87

390937

10344195

DELTA7-sterol-C5-desaturase: molecular characterization and functional expression of wild-type and mutant alleles

1999

Husselstein, T.; Schaller, H.; Gachotte, D.; Benveniste, P.

Plant Mol. Biol.

39

891-906

684606

17225097

Ergosterol production from molasses by genetically modified Saccharomyces cerevisiae

2007

He, X.; Guo, X.; Liu, N.; Zhang, B.

Appl. Microbiol. Biotechnol.

75

55-60

745462

25230683

Sterols of Saccharomyces cerevisiae erg6 knockout mutant expressing the Pneumocystis carinii S-adenosylmethionine sterol C-24 methyltransferase (SAM SMT)

2015

Kaneshiro, E.; Johnston, L.; Nkinin, S.; Romero, B.; Giner, J.

J. Eukaryot. Microbiol.

62

298-306

Links to other databases for ergosta-5,7,22,24(241)-tetraen-3beta-ol

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Show Links (1 entry)

ChEBI

PubChem

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