Ligand ergosterol

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Basic Ligand Information

Molecular Structure
Picture of ergosterol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C28H44O
ergosterol
DNVPQKQSNYMLRS-APGDWVJJSA-N
Synonyms:
erosterol

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ergosterol + O2 = dehydroergosterol + H2O2
show the reaction diagram
-
UDP-glucose + ergosterol = UDP + ergosterol 3-beta-D-glucoside
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (10 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ergosterol + reduced adrenodoxin + O2 = 24-hydroxyergosterol + 26-hydroxyergosterol + 28-hydroxyergosterol + oxidized adrenodoxin + H2O
show the reaction diagram
-
ergosterol + ferrocytochrome b5 + O2 + H+ = lanosterol + ferricyctochrome b5 + H2O
show the reaction diagram
-
ergosterol + NADP+ = ?
show the reaction diagram
-
ergosterol + S-adenosyl-L-methionine = ?
show the reaction diagram
-
oleoyl-CoA + ergosterol = CoA + ergosteryl oleate
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H+ = ergosterol + NADP+
show the reaction diagram
-
-
ergosteryl beta-D-glucoside + H2O = ergosterol + beta-D-glucose
show the reaction diagram
-
-

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Inhibitor in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
non-competetively, concentration 0.025 mM
-
inhibits esterification of exogenous cholesterol
-
2 mM, 73% inhibition
-

Enzyme Kinetic Parameters

KM Value (3 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.21
-
-

Ki Value (10 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.037
-
pH 7.6, 37°C
0.08
-
-

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0645
-
pH 7.5, 37°C

References & Links

Links to other databases for ergosterol

ChEBI
PubChem
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PubChem