Ligand leukotriene E4

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Basic Ligand Information

Molecular Structure
Picture of leukotriene E4 (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C23H37NO5S
leukotriene E4
HSESOQWUWUWSEX-ZUQRMPMESA-M
Synonyms:
(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate


Show all pahtways known for Show all BRENDA pathways known for leukotriene E4

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate + NADPH + O2 = 20-hydroxy-leukotriene E4 + NADP+ + H2O
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ATP + H2O + leukotriene E4/in = ADP + phosphate + leukotriene E4/out
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ATP + H2O + leukotriene E4/in = ADP + phosphate + leukotriene E4/out
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Substrate in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate + NADPH + O2 = 20-hydroxy-leukotriene E4 + NADP+ + H2O
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acetyl-CoA + leukotriene E4 = CoA + N-acetyl-leukotriene E4
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leukotriene E4 = ?
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Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
leukotriene D4 + H2O = leukotriene E4
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Inhibitor in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

References & Links

Links to other databases for leukotriene E4

ChEBI
PubChem
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PubChem