Ligand leukotriene E4
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Basic Ligand Information
Molecular Structure
C23H37NO5S
leukotriene E4
OTZRAYGBFWZKMX-FRFVZSDQSA-N
(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate
Show all BRENDA pathways known for leukotriene E4
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)
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(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate + NADPH + O2 = 20-hydroxy-leukotriene E4 + NADP+ + H2O
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ATP + H2O + leukotriene E4/in = ADP + phosphate + leukotriene E4/out
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)
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ATP + H2O + leukotriene E4/in = ADP + phosphate + leukotriene E4/out
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Substrate in Enzyme-catalyzed Reactions (5 results)
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(7E,9E,11Z,14Z)-(5S,6R)-6-(cystein-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate + NADPH + O2 = 20-hydroxy-leukotriene E4 + NADP+ + H2O
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acetyl-CoA + leukotriene E4 = CoA + N-acetyl-leukotriene E4
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ATP + H2O + leukotriene E4/in = ADP + phosphate + leukotriene E4/out
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leukotriene E4/in + ATP + H2O = leukotriene E4/out + ADP + phosphate
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Product in Enzyme-catalyzed Reactions (3 results)
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leukotriene D4 + H2O = leukotriene E4
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ATP + H2O + leukotriene E4/in = ADP + phosphate + leukotriene E4/out
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leukotriene E4/in + ATP + H2O = leukotriene E4/out + ADP + phosphate
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Inhibitor in Enzyme-catalyzed Reactions (1 result)
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Enzyme Kinetic Parameters
References & Links
Literature References (7)
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Isolation from rat kidney of a cytosolic high molecular weight cysteine-S-conjugate beta-lyase with activity toward leukotriene E4
1995
Abraham, D.G.; Patel, P.P.; Cooper, A.J.L.
J. Biol. Chem.
270
180-188
P-glycoproteins and multidrug resistance
1996
Bellamy, W.T.
Annu. Rev. Pharmacol. Toxicol.
36
161-183
omega-Oxidation of cysteine-containing leukotrienes by rat-liver microsomes
1987
Orning, L.
Eur. J. Biochem.
170
77-85
Halothane metabolism. Impairment of hepatic omega-oxidation of leukotrienes in vivo and in vitro
1992
Huwyler, J.; Jedlitschky, G.; Keppler, D.; Gut, J.
Eur. J. Biochem.
206
869-897
Purification of human leukotriene C4 synthase from dimethylsulfoxide-differentiated U937 cells
1992
Nicholson, D.W.; Klemba, M.W.; Rasper, D.M.; Metters, K.M.; Zamboni, R.J.
Eur. J. Biochem.
209
725-734
Molecular identification of NAT8 as the enzyme that acetylates cysteine S-conjugates to mercapturic acids
2010
Veiga-da-Cunha, M.; Tyteca, D.; Stroobant, V.; Courtoy, P.J.; Opperdoes, F.R.; Van Schaftingen, E.
J. Biol. Chem.
285
18888-18898
Multidrug resistance protein 1 (MRP1, ABCC1), a multitasking ATP-binding cassette (ABC) transporter
2014
Cole, S.P.
J. Biol. Chem.
289
30880-30888
Links to other databases for leukotriene E4
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