Ligand L(-)threo-Sphinganine
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Basic Ligand Information
Molecular Structure

C18H39NO2
L(-)threo-Sphinganine
OTKJDMGTUTTYMP-ROUUACIJSA-N
dihydro-D-erythro-sphingosine, DL-threo-dihydrosphinganine, L-(-)-threo-sphinganine, L-threo-dihydrosphingosine, L-threo-sphinganine
Roles as Enzyme Ligand
In Vivo Product in Enzyme-catalyzed Reactions (1 result)
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3-oxosphinganine + NADPH + H+ = D-erythro-dihydrosphingosine + L-threo-dihydrosphingosine + NADP+
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Substrate in Enzyme-catalyzed Reactions (1 result)
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ATP + L-(-)-threo-sphinganine = ADP + L-(-)-threo-sphinganine 1-phosphate
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Product in Enzyme-catalyzed Reactions (3 results)
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3-oxosphinganine + NADPH + H+ = D-erythro-dihydrosphingosine + L-threo-dihydrosphingosine + NADP+
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dihydro-N-myristoyl-D-erythro-sphingosine + H2O = dihydro-D-erythro-sphingosine + myristate
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dihydro-N-palmitoyl-D-erythro-sphingosine + H2O = dihydro-D-erythro-sphingosine + palmitate
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Inhibitor in Enzyme-catalyzed Reactions (3 results)
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Enzyme Kinetic Parameters
KM Value (1 result)
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References & Links
Literature References (4)
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Properties and specificities of sphingosine kinase from blood platelets
1973
Stoffel, W.; Hellenbroich, B.; Heimann, G.
Hoppe-Seyler's Z. Physiol. Chem.
354
1311-1316
Inhibition of sphingosine kinase in vitro and in platelets. Implications for signal transduction pathways
1992
Buehrer, B.M.; Bell, R.M.
J. Biol. Chem.
267
3154-3159
Inhibition of tyrosylprotein sulfotransferase by sphingosine and its reversal by acidic phospholipids
1993
Kasinathan, C.; Sundaram, P.; Slomiany, B.L.; Slomiany, A.
Biochemistry
32
1194-1198
Sphingosine kinase: biochemical and cellular regulation and role in disease
2006
Taha, T.A.; Hannun, Y.A.; Obeid, L.M.
J. Biochem. Mol. Biol.
39
113-131
Links to other databases for L(-)threo-Sphinganine