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Ligand 8-azaguanine

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Basic Ligand Information

Molecular Structure
Picture of 8-azaguanine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C4H4N6O
8-azaguanine
LPXQRXLUHJKZIE-UHFFFAOYSA-N
Synonyms:
8-aza-2-aminohypoxanthine, Azaguanine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
8-azaguanine + alpha-D-ribose 1-phosphate = 8-azaguanosine + phosphate
show the reaction diagram

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
8-azaguanosine + phosphate = 8-azaguanine + alpha-D-ribose 1-phosphate
show the reaction diagram

Substrate in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
8-azaguanine + 5-phospho-alpha-D-ribose 1-diphosphate = 8-aza-IMP + diphosphate
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
8-azaguanosine + phosphate = 8-azaguanine + alpha-D-ribose 1-phosphate
show the reaction diagram

Inhibitor in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.05 mM, complete inhibition of exchange between free guanine with guanine
-
10 mM, 81.7% inhibition
-
43% inhibition at 2.9 mM
-
competitive inhibition
-
0.5 mM, 40% inhibition
-

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
7
-
wild-type, pH 7.5, 25°C

KM Value (16 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (3 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
2.6
-
-
0.000023
-
pH and temperature not specified in the publication
4.7
-
37°C, pH 8.2

References & Links

Links to other databases for 8-azaguanine

ChEBI
PubChem
ChEBI
PubChem