Ligand 2-hydroxyestradiol

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Basic Ligand Information

Molecular Structure
Picture of 2-hydroxyestradiol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C18H24O3
2-hydroxyestradiol
DILDHNKDVHLEQB-XSSYPUMDSA-N
Synonyms:
2-hydroxy-17beta-estradiol, 2-hydroxy-estradiol, 2-hydroxyestradiol-17beta, 2-hydroxyestrogen, 2OH-17beta estradiol

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (14 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3'-phosphoadenylylsulfate + 2-hydroxyestradiol = adenosine 3',5'-bisphosphate + estradiol 2-sulfate
show the reaction diagram
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3'-phosphoadenylylsulfate + 2-hydroxy-estradiol = adenosine 3',5'-bisphosphate + ?
show the reaction diagram
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3'-phosphoadenylylsulfate + 2-hydroxyestradiol = adenosine 3',5'-bisphosphate + 2-hydroxyestradiol sulfate
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.01 mM, 67% inhibition, reaction with 0.002 mM estradiol
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0.01 mM, 17% inhibition
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noncompetitive
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3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (18 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

Ki Value (4 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE

IC50 Value (3 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE

References & Links

Links to other databases for 2-hydroxyestradiol

ChEBI
PubChem
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PubChem