Ligand glyburide

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Basic Ligand Information

Molecular Structure
Picture of glyburide (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C23H28ClN3O5S
glyburide
ZNNLBTZKUZBEKO-UHFFFAOYSA-N
Synonyms:
glibencalmide

Show all pahtways known for Show all pathways known for glyburide

Roles as Enzyme Ligand

Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
; isoform PanK1b is activated by glyburide
-
presence of 5 mM ATP, slightly stimulating up to 1 mM, inhibitory above. Presence of 0.05 mM ATP, stimulating at least up to 3 mM
-

Inhibitor in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
an open-channel blocker
-
presence of 5 mM ATP, slightly stimulating up to 1 mM, inhibitory above. Presence of 0.05 mM ATP, stimulating at least up to 3 mM
-

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.0068
-
isoform PanK3, at pH 7.5 and 37°C

References & Links

Links to other databases for glyburide

ChEBI
PubChem
ChEBI
PubChem