Ligand 1-hydroxy-2-naphthoate

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Basic Ligand Information

Molecular Structure
Picture of 1-hydroxy-2-naphthoate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C11H8O3
1-hydroxy-2-naphthoate
SJJCQDRGABAVBB-UHFFFAOYSA-N
Synonyms:
1-hydroxy-2-naphthoic acid, 1-hydroxy 2 naphthoate, 1-hydroxynaphthalene-2-carboxylic acid

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (13 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1-hydroxy-2-naphthoate + O2 = ?
show the reaction diagram
1-hydroxy-2-naphthoate + O2 = (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate
show the reaction diagram
-
farnesyl diphosphate + 1-hydroxy-2-naphthoate = 2-farnesyl-1-naphthol + phosphate + CO2
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
1-hydroxy-2-naphthoyl-CoA + H2O = CoA + 1-hydroxy-2-naphthoate
show the reaction diagram
-
-

Inhibitor in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
substrate inhibition
-
0.33 mM, 19% of wild type enzyme activity remaining
strong competitive inhibition of salicylate hydroxylation
-
reversible
-

3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (13 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (15 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.004
-
-

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.116
-
substrate inhibition
0.00068
-
30°C, pH 7.0

References & Links

Links to other databases for 1-hydroxy-2-naphthoate

ChEBI
PubChem
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PubChem