Ligand 4-hydroxy-2-oxohexanoic acid

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Basic Ligand Information

Molecular Structure
Picture of 4-hydroxy-2-oxohexanoic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H10O4
4-hydroxy-2-oxohexanoic acid
ALFQPWXBAWHVDP-UHFFFAOYSA-N
Synonyms:
2-keto-4-hydroxyhexanoate, 4-hydroxy-2-ketohexanoic acid, 4-hydroxy-2-oxohexanoate

Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(2Z,4Z)-2-hydroxyhexa-2,4-dienoic acid + H2O = 4-hydroxy-2-oxohexanoic acid
show the reaction diagram
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-

Substrate in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
4-hydroxy-2-ketohexanoic acid = ?
show the reaction diagram
-
4-hydroxy-2-oxohexanoate = ?
show the reaction diagram
-
4-hydroxy-2-oxohexanoate = ?
show the reaction diagram
-
4-hydroxy-2-oxohexanoate = propionaldehyde + pyruvate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
propionaldehyde + pyruvate = 4-hydroxy-2-oxohexanoate
show the reaction diagram
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-
pyruvate + propionaldehyde = 4-hydroxy-2-oxohexanoate
show the reaction diagram
-
-
(2Z,4Z)-2-hydroxyhexa-2,4-dienoic acid + H2O = 4-hydroxy-2-oxohexanoic acid
show the reaction diagram
-
-
2-hydroxyhexa-2,4-dienoate + H2O = 2-keto-4-hydroxyhexanoate
show the reaction diagram
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-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (16 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
447
-
data for Ni2+-activated YfaU
229
-
pH 8.0, 25°C
447
-
pH 8.0, 25°C, 25°C, Ni2+-activated

KM Value (16 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.05
-
data for Ni2+-activated YfaU
0.16
-
pH 8.0, 25°C
0.05
-
pH 8.0, 25°C, 25°C, Ni2+-activated

References & Links

Links to other databases for 4-hydroxy-2-oxohexanoic acid

ChEBI
PubChem
ChEBI
PubChem