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Ligand 3-oxo-3-phenylpropionic acid

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (2 results)

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Show Natural Product (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.6.1.18

pyruvate + beta-phenylalanine = L-alanine + 3-oxo-phenylpropanoate

0

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6.4.1.8

2 ATP + acetophenone + HCO3- + H2O + H+ = 2 ADP + 2 phosphate + 3-oxo-3-phenylpropanoate

0

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Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.2.1.30

3-oxo-3-phenylpropanoate + NADPH + H+ + ATP = 3-oxo-3-phenylpropanal + NADP+ + AMP + diphosphate

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4.1.1.4

3-oxo-3-phenylpropionic acid + H+ = ?

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Product in Enzyme-catalyzed Reactions (8 results)

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Show Product (8 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.6.1.18

rac-beta-phenylalanine + pyruvate = 3-oxo-3-phenylpropanoate + L-alanine

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2.6.1.18

2-oxoglutarate + (S)-beta-phenylalanine = L-glutamate + 3-oxo-phenylpropanoate

0

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2.6.1.18

2-oxoglutarate + rac-beta-phenylalanine = L-glutamate + 3-oxo-phenylpropanoate

0

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2.6.1.18

pyruvate + beta-phenylalanine = L-alanine + 3-oxo-phenylpropanoate

0

-

2.6.1.18

4 entries

2.6.1.21

beta-phenylalanine + pyruvate = 3-oxo-3-phenylpropionic acid + D-alanine

0

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2.6.1.5

(S)-beta-phenylalanine + 2-oxoglutarate = 3-oxo-3-phenylpropionic acid + L-glutamate

0

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2.6.1.5

(S)-beta-phenylalanine + pyruvate = 3-oxo-3-phenylpropionic acid + L-alanine

0

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2.6.1.5

2 entries

6.4.1.8

2 ATP + acetophenone + HCO3- + H2O + H+ = 2 ADP + 2 phosphate + 3-oxo-3-phenylpropanoate

0

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Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (5 results)

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Show Turnover Number (5 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

1.2.1.30

0.3

-

pH 7.3, 30°C

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1.2.1.30

0.618

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pH 7.5, 30°C

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1.2.1.30

1.05

-

pH 7.5, 30°C

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1.2.1.30

1.25

-

pH 8.0, 30°C

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1.2.1.30

1.42

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pH 7.8, 30°C

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1.2.1.30

5 entries

K_M Value (6 results)

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Show KM Value (6 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

1.2.1.30

0.27

-

pH 8.0, 30°C

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1.2.1.30

0.29

-

pH 7.5, 30°C

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1.2.1.30

0.39

-

pH 7.5, 30°C

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1.2.1.30

0.55

-

pH 7.8, 30°C

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1.2.1.30

3.8

-

pH 7.3, 30°C

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1.2.1.30

5 entries

4.1.1.4

10

-

-

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References & Links

Literature References (2)

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Show Reference (2 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

4527

-

Acetoacetate decarboxylase

1972

Fridovich, I.

The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )

6

255-270

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28450969

Characterization of carboxylic acid reductases as enzymes in the toolbox for synthetic chemistry

2017

Finnigan, W.; Thomas, A.; Cromar, H.; Gough, B.; Snajdrova, R.; Adams, J.P.; Littlechild, J.A.; Harmer, N.J.

ChemCatChem

9

1005-1017

Links to other databases for 3-oxo-3-phenylpropionic acid

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Show Links (1 entry)

ChEBI

PubChem