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BRENDA support

Ligand (2R,3R)-2,3-dihydroxy-3-methylpentanoic acid

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Basic Ligand Information

Molecular Structure
Picture of (2R,3R)-2,3-dihydroxy-3-methylpentanoic acid (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H12O4
(2R,3R)-2,3-dihydroxy-3-methylpentanoic acid
PDGXJDXVGMHUIR-UJURSFKZSA-N
Synonyms:
(2R,3R)-2,3-dihydroxy-3-methylpentanoate, (2R,3R)-2,3-dihydroxy-3-methylvalerate, (R)-2,3-dihydroxy-3-methylpentanoate, 2R,3R-2,3-dihydroxy-3-methylpentanoate
Pathway Source
Pathways
KEGG
2-Oxocarboxylic acid metabolism, Biosynthesis of amino acids, Biosynthesis of secondary metabolites, Valine, leucine and isoleucine biosynthesis
MetaCyc
L-isoleucine biosynthesis I (from threonine), L-isoleucine biosynthesis II, L-isoleucine biosynthesis III, L-isoleucine biosynthesis IV

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (1 result)

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EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(2R,3R)-2,3-dihydroxy-3-methylpentanoate = 3-methyl-2-oxopentanoate + H2O
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (1 result)

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EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-aceto-2-hydroxybutyrate + NADP+ = (2R,3R)-2,3-dihydroxy-3-methylvalerate + NADPH + H+
show the reaction diagram
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3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

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EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

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EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (1 result)

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EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.33
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-

References & Links

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Links to other databases for (2R,3R)-2,3-dihydroxy-3-methylpentanoic acid

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ChEBI
PubChem
ChEBI
PubChem