print visible entries

print all entries

Ligand [alginate]-alpha-L-guluronate

Basic Ligand Information

Molecular Structure

Related pathways

Show all BRENDA pathways known for [alginate]-alpha-L-guluronate

close all tables

open all tables

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

top print hide

Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

5.1.3.37

[alginate]-alpha-L-guluronate = [mannuronan]-beta-D-mannuronate

771765

-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

top print hide

Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

5.1.3.37

[mannuronan]-beta-D-mannuronate = [alginate]-alpha-L-guluronate

-

-

Substrate in Enzyme-catalyzed Reactions (2 results)

top print hide

Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

5.1.3.37

[alginate]-alpha-L-guluronate = [mannuronan]-beta-D-mannuronate

771765, 772023

-

5.1.3.37

[alginate]-beta-D-mannuronate = [alginate]-alpha-L-guluronate

734128, 734129, 733606, 733608

-

5.1.3.37

2 entries

Product in Enzyme-catalyzed Reactions (2 results)

top print hide

Show Product (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

5.1.3.37

[alginate]-beta-D-mannuronate = [alginate]-alpha-L-guluronate

-

-

5.1.3.37

[mannuronan]-beta-D-mannuronate = [alginate]-alpha-L-guluronate

-

-

5.1.3.37

2 entries

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (1 result)

top print hide

Show Turnover Number (1 entry)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

5.1.3.37

14

-

pH 6.8, 37°C

734129

K_M Value (1 result)

top print hide

Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

5.1.3.37

0.018

-

pH 6.8, 37°C

734129

References & Links

Literature References (6)

top print hide

Show Reference (6 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

733606

-

Enzymatic modification of alginates with the mannuronan C-5epimerase AlgE4 enhances their solubility at low pH

2006

Hartmann, M.; Dentini, M.; Ingar Draget, K; Skjak-Braek, G.

Carbohydr. Polym.

63

257-262

733608

-

Purification of mannuronan C-5-epimerase by affinity chromatography on alginate-Sepharose

1982

Skjak-Braek, G.; Larsen, BB.

Carbohydr. Res.

103

137-140

734128

9812987

The Azotobacter vinelandii mannuronan C-5-epimerase AlgE1 consists of two separate catalytic domains

1998

Ertesvag, H.; Hoidal, H.K.; Skjak-Braek, G.; Valla, S.

J. Biol. Chem.

273

30927-30932

734129

10212201

The recombinant Azotobacter vinelandii mannuronan C-5-epimerase AlgE4 epimerizes alginate by a nonrandom attack mechanism

1999

Hoidal, H.K.; Ertesvag, H.; Skjak-Braek, G.; Stokke, B.T.; Valla, S.

J. Biol. Chem.

274

12316-12322

771765

33822050

Insights into the roles of charged residues in substrate binding and mode of action of mannuronan C-5 epimerase AlgE4

2021

Gaardlos, M.; Samsonov, S.A.; Sletmoen, M.; Hjornevik, M.; Saetrom, G.I.; Tondervik, A.; Aachmann, F.L.

Glycobiology

31

1616-1635

772023

33220370

Properties and potential applications of mannuronan C5-epimerase A biotechnological tool for modifying alginate

2021

Ci, F.; Jiang, H.; Zhang, Z.; Mao, X.

Int. J. Biol. Macromol.

168

663-675

Links to other databases for [alginate]-alpha-L-guluronate

top print hide

Show Links (1 entry)