Ligand N-methylnicotinate
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Basic Ligand Information
Molecular Structure
C7H7NO2
N-methylnicotinate
WWNNZCOKKKDOPX-UHFFFAOYSA-N
1-methylnicotinate, Trigonelline
Roles as Enzyme Ligand
In Vivo Product in Enzyme-catalyzed Reactions (2 results)
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S-adenosyl-L-methionine + nicotinate = S-adenosyl-L-homocysteine + 1-methylnicotinate
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S-adenosyl-L-methionine + nicotinate = S-adenosyl-L-homocysteine + N-methylnicotinate
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Substrate in Enzyme-catalyzed Reactions (1 result)
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trigonelline + H2O + NADP+ = ?
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Product in Enzyme-catalyzed Reactions (3 results)
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S-adenosyl-L-methionine + nicotinate = S-adenosyl-L-homocysteine + 1-methylnicotinate
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S-adenosyl-L-methionine + nicotinate = S-adenosyl-L-homocysteine + N-methylnicotinate
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1-methylnicotinamide + H2O = 1-methylnicotinate + NH3
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Inhibitor in Enzyme-catalyzed Reactions (2 results)
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i.e. N-methylnicotinic acid
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Enzyme Kinetic Parameters
IC50 Value (1 result)
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References & Links
Literature References (5)
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Biosynthesis of trigonelline
1960
Joshi, J.G.; Handler, P.
J. Biol. Chem.
235
2981-2983
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Biosynthesis and metabolism of trigonelline in Lemna paucicostata 151
1989
Taguchi, H.; Nishitani, H.; Okumura, K.; Shimabayashi, Y.; Iwai, K.
Agric. Biol. Chem.
53
2867-2871
Purification and properties of S-adenosyl-L-methionine:nicotinic acid-N-methyltransferase from cell suspension cultures of Glycine max L
1988
Upmeier, B.; Gross, W.; Köster, S.; Barz, W.
Arch. Biochem. Biophys.
262
445-454
Properties of the selenium- and molybdenum-containing nicotinic acid hydroxylase from Clostridium barkeri
1996
Gladyshev, V.N.; Khangulov, S.V.; Stadtman, T.C.
Biochemistry
35
212-223
Acetylcholinesterase enzyme inhibitory potential of standardized extract of Trigonella foenum graecum L. and its constituents
2010
Satheeshkumar, N.; Mukherjee, P.K.; Bhadra, S.; Saha, B.P.
Phytomedicine
17
292-295
Links to other databases for N-methylnicotinate
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