Ligand chloroform

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Basic Ligand Information

Molecular Structure
Picture of chloroform (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
CHCl
chloroform
HEDRZPFGACZZDS-UHFFFAOYSA-N
Synonyms:
CHCl3, Trichloromethane

Show all pahtways known for Show all pathways known for chloroform

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
CHCl3 + H2O = ?
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
CHCl3 + H2O = ?
show the reaction diagram
-
trichloromethane + H2O = ? + chloride
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
7% activation at 0.5% w/v
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slight activation
-
at 25% v/v, 30C, 130% activity after 24 h, 140% after 48 h
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50%, 2fold higher activty compared to water as solvent
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cell-bound PVA activity shows an eightfold increase upon treatment with chloroform at 0.005 ml/mg dry biomass for 10 min upon permeabilization
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stimulates
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Inhibitor in Enzyme-catalyzed Reactions (16 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
21% inhibition in buffer without NaCl, 19% inhibition in buffer with 600 mM NaCl
-
inhibits 80% at 10%
-
1 h, 20% loss of activity by 20% (v/v), 65% loss of activity by 50% (v/v)
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the cross-linked enzyme aggregate shows about 30% residual activity after incubation in chloroform for about 3 h
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Mn-SOD
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20%
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excess chloroform inactivates
-
50% (v/v), 2 h incubation, 66% loss of activity
-
completely inhibits activity
-
inhibitory at 3% (v/v)
-
about 25% residual activity at 10% (v/v)
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Enzyme Kinetic Parameters

References & Links

Links to other databases for chloroform

ChEBI
PubChem
ChEBI
PubChem