Ligand questin
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Basic Ligand Information
C16H12O5
questin
UUNPIWCQMVNINR-UHFFFAOYSA-N
Related pathways
MetaCyc
geodin biosynthesis
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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questin + NADPH + H+ + O2 = demethylsulochrin + NADP+
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)
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S-adenosyl-L-methionine + emodin = S-adenosyl-L-homocysteine + questin
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Substrate in Enzyme-catalyzed Reactions (1 result)
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questin + NADPH + H+ + O2 = demethylsulochrin + NADP+
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Product in Enzyme-catalyzed Reactions (2 results)
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S-adenosyl-L-methionine + emodin = S-adenosyl-L-homocysteine + questin
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S-adenosyl-L-methionine + emodin = S-adenosyl-L-homocysteine + questin
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Inhibitor in Enzyme-catalyzed Reactions (1 result)
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inhibition of p56lck and c-Src
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Enzyme Kinetic Parameters
References & Links
Literature References (3)
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A novel anthraquinone ring cleavage enzyme from Aspergillus terreus
1988
Fuji, I.; Ebizuka, Y.; Sankawa, U.
J. Biochem.
103
878-883
Plant-derived protein tyrosine kinase inhibitors as anticancer agents
2004
Hollosy, F.; Keri, G.
Curr. Med. Chem. Anticancer Agents
4
173-197
Sulochrins and alkaloids from a fennel endophyte Aspergillus sp. FVL2
2021
Shaaban, M.; Abdel-Razek, A.S.; Previtali, V.; Clausen, M.H.; Gotfredsen, C.H.; Laatsch, H.; Ding, L.
Nat. Prod. Res.
2021
1-11
Links to other databases for questin