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Ligand phosphatidyl-N,N-dimethylethanolamine

Basic Ligand Information

Molecular Structure

Show all BRENDA pathways known for phosphatidyl-N,N-dimethylethanolamine

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.17

S-adenosyl-L-methionine + phosphatidyl-N,N-dimethylethanolamine = S-adenosyl-L-homocysteine + phosphatidylcholine

485175, 485195

-

In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.17

S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine

485175, 485195

-

Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.17

S-adenosyl-L-methionine + phosphatidyl-N,N-dimethylethanolamine = S-adenosyl-L-homocysteine + phosphatidylcholine

485175, 485195

-

2.1.1.71

S-adenosyl-L-methionine + phosphatidyl-N,N-dimethylethanolamine = S-adenosyl-L-homocysteine + phosphatidylcholine

485193, 485554, 485555, 485559, 485560, 485166, 704482

-

Product in Enzyme-catalyzed Reactions (3 results)

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Show Product (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.1.1.17

S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine

0, 485175, 485195

-

2.1.1.71

S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N,N-dimethylethanolamine

0

-

2.1.1.71

S-adenosyl-L-methionine + phosphatidyl-N-monomethylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine

0

-

2.1.1.71

2 entries

Enzyme Kinetic Parameters

K_M Value (4 results)

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Show KM Value (4 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.1.1.17

0.45

-

-

485164

2.1.1.17

2.12

-

-

485171

2.1.1.71

0.059

-

-

485166

2.1.1.71

0.18

-

-

485166

2.1.1.17

2 entries

2.1.1.71

2 entries

References & Links

Literature References (11)

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Show Reference (11 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

485164

1495417

Phosphatidylethanolamine N-methyltransferase from rat liver

1992

Ridgway, N.D.; Vance, D.E.

Methods Enzymol.

209

366-374

485166

2198947

Phosphatidylethanolamine methyltransferase and phospholipid methyltransferase activities from Saccharomyces cerevisiae. Enzymological and kinetic properties

1990

Gaynor, P.M.; Carman, G.M.

Biochim. Biophys. Acta

1045

156-163

485171

3182819

Kinetic mechanism of phosphatidylethanolamine N-methyltransferase

1988

Ridgway, N.D.; Vance, D.E.

J. Biol. Chem.

263

16864-16871

485175

-

Purification and characterization of phosphatidylethanolamine N-methyltransferase from Zymomonas mobilis

1987

Tahara, Y.; Ogawa, Y.; Sakakibara, T.; Yamada, Y.

Agric. Biol. Chem.

51

1425-1430

485193

7641846

Phosphatidylethanolamine N-methyltransferase activity in isolated rod outer segments from bovine retina

1995

Roque, M.E.; Giusto, N.M.

Exp. Eye Res.

60

631-643

485195

10760824

Inactivation of phosphatidylethanolamine N-methyltransferase-2 in aflatoxin-induced liver cancer and partial reversion of the neoplastic phenotype by PEMT transfection of hepatoma cells

2000

Tessitore, L.; Sesca, E.; Vance, D.E.

Int. J. Cancer

86

362-367

485554

438165

Conversion of phosphatidylethanolamine to phosphatidylcholine in rat liver. Partial purification and characterization of the enzymatic activities

1979

Schneider, W.J.; Vance, D.E.

J. Biol. Chem.

254

3886-3891

485555

25437

Identification and properties of two methyltransferases in conversion of phosphatidylethanolamine to phosphatidylcholine

1978

Hirata, F.; Viveros, O.H.; Diliberto, E.J.; Axelrod, J.

Proc. Natl. Acad. Sci. USA

75

1718-1721

485559

9406167

Adriamycin depresses in vivo and in vitro phosphatidylethanolamine N-methylation in rat heart sarcolemma

1997

Iliskovic, N.; Panagia, V.; Slezak, J.; Kumar, D.; Li, T.; Singal, P.K.

Mol. Cell. Biochem.

176

235-240

485560

7305396

Evidence for two methyltransferase involved in the conversion of phosphatidylethanolamine to phosphatidylcholine in the rat liver

1981

Sastry, B.V.R.; Statham, C.N.; Axelrod, J.; Hirata, F.

Arch. Biochem. Biophys.

211

762-773

704482

19366698

Functional characterization of phospholipid N-methyltransferases from Arabidopsis and soybean

2009

Keogh, M.R.; Courtney, P.D.; Kinney, A.J.; Dewey, R.E.

J. Biol. Chem.

284

15439-15447

Links to other databases for phosphatidyl-N,N-dimethylethanolamine

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