Ligand N6-hydroxy-L-lysine
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Basic Ligand Information
Molecular Structure
C6H14N2O3
N6-hydroxy-L-lysine
FZQOIMPLZAYIKU-YFKPBYRVSA-N
6-N-hydroxy-L-lysine, L-N6-hydroxylysine, N6-hydroxy-L-Lys, N6-hydroxylysine
Show all BRENDA pathways known for N6-hydroxy-L-lysine
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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acetyl-CoA + L-N6-hydroxylysine = CoA + N6-acetyl-N6-hydroxylysine
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In Vivo Product in Enzyme-catalyzed Reactions (3 results)
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L-lysine + NADH + H+ + O2 = N6-hydroxy-L-lysine + NAD+ + H2O
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L-lysine + NADPH + H+ + O2 = N6-hydroxy-L-lysine + NADP+ + H2O
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L-lysine + NADPH + O2 = N6-hydroxy-L-lysine + NADP+ + H2O
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Substrate in Enzyme-catalyzed Reactions (2 results)
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N6-hydroxy-L-lysine + pyruvate + NADPH + H+ = ? + NADP+ + H2O
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acetyl-CoA + L-N6-hydroxylysine = CoA + N6-acetyl-N6-hydroxylysine
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Product in Enzyme-catalyzed Reactions (6 results)
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L-lysine + NADPH + H+ + O2 = N6-hydroxy-L-lysine + NADP+ + H2O
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L-Lys + NADPH + O2 = N6-Hydroxy-L-Lys + NADP+ + H2O
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L-lysine + iodine + O2 = N6-hydroxy-L-lysine + iodate + H2O
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L-lysine + NADH + H+ + O2 = N6-hydroxy-L-lysine + NAD+ + H2O
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L-lysine + NADPH + H+ + O2 = N6-hydroxy-L-lysine + NADP+ + H2O
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L-lysine + NADPH + O2 = N6-hydroxy-L-lysine + NADP+ + H2O
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Enzyme Kinetic Parameters
kcat Value (Turnover Number) (1 result)
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KM Value (1 result)
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References & Links
Literature References (5)
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Isolation and some properties of lysine N6-hydroxylase from Escherichia coli strain EN222
1989
Plattner, H.J.; Pfefferle, P.; Romaguera, A.; Waschutza, S.; Dieckman, H.
Biol. Met.
2
1-5
FAD and substrate analogs as probes for lysine N6-hydroxylase from Escherichia coli EC 222
1993
Macheroux, P.; Plattner, H.J.; Romaguera, A.; Diekmann, H.
Eur. J. Biochem.
213
995-1002
Isolation and properties of N epsilon-hydroxylysine:acetyl coenzyme A nepsilon-transacetylase from Escherichia coli pABN11
1986
Coy, M.; Paw, B.H.; Bindereif, A.; Neilands, J.B.
Biochemistry
25
2485-2489
Aerobactin biosynthesis and transport genes of plasmid ColV-K30 in Escherichia coli K-12
1986
Lorenzo de, V.; Bindereif, A.; Paw, B.H.; Neilands, J.B.
J. Bacteriol.
165
570-578
The gene CBO0515 from Clostridium botulinum strain Hall A encodes the rare enzyme N5-(carboxyethyl) ornithine synthase, EC 1.5.1.24
2010
Thompson, J.; Hill, K.K.; Smith, T.J.; Pikis, A.
J. Bacteriol.
192
1151-1155
Links to other databases for N6-hydroxy-L-lysine
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