Ligand S-(2-aminoethyl)-L-cysteine

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Basic Ligand Information

Molecular Structure
Picture of S-(2-aminoethyl)-L-cysteine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H12N2O2S
S-(2-aminoethyl)-L-cysteine
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Synonyms:
(S)-2-aminoethyl-L-Cys, (S)-aminoethylcysteine, 2-aminoethyl-L-cysteine, 4-thia-(R)-lysine, aminoethylcysteine, L-4-thialysine, L-S-aminoethylcysteine, L-thialysine, S-(2-aminoethyl)-L-Cys, S-(2-aminoethyl)-L- cysteine, S-(beta-aminoethyl)-L-cysteine, S-2-aminoethyl-L-cysteine, S-2-aminoethylcysteine, S-aminoethyl-L-Cys, S-aminoethyl-L-cysteine, S-aminoethylcysteine, thialysine

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (19 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(S)-2-Aminoethyl-L-Cys + NADPH + O2 = ?
show the reaction diagram
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S-(2-aminoethyl)-L-cysteine + NADP+ + H2O = S-(2-oxoethyl)-L-cysteine + NADPH + NH3
show the reaction diagram
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S-(beta-aminoethyl)-L-cysteine + NAD+ = ?
show the reaction diagram
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S-(2-aminoethyl)-L- cysteine + pyruvate + NADPH + H+ = ? + NADP+ + H2O
show the reaction diagram
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S-2-aminoethyl-L-cysteine + 2-oxoglutarate + NADPH = ?
show the reaction diagram
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S-2-aminoethyl-L-cysteine + 8-amino-7-oxononanoate = ? + (7S,8R)-diaminononanoate
show the reaction diagram
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S-Aminoethyl-L-Cys = 1-Amino-2-(S-aminoethyl)mercaptoethane + CO2
show the reaction diagram
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L-4-thialysine = ?
show the reaction diagram
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S-(2-aminoethyl)-L-Cys + H2O = ?
show the reaction diagram
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S-aminoethyl-L-cysteine + H2O = NH3 + pyruvate + cysteamine
show the reaction diagram
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4-thia-(R)-lysine = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-serine + cysteamine = L-thialysine
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
5 mM, 2.32fold activation
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Inhibitor in Enzyme-catalyzed Reactions (24 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.001 mM in 0.06 mM Tris-HCl buffer
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3D Structure of Enzyme-Ligand-Complex (PDB) (2 results)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (1 result)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
17.8
-
pH 8.3, 30°C

KM Value (7 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
17
-
-
2
-
pH 8.0, 37°C
2.75
-
pH 8.0, 37°C
0.47
-
-
0.27
-
pH 8.3, 30°C

Ki Value (25 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.007
-
-
4.6
-
-

IC50 Value (3 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.000045
-
pH 8.5, 21°C

References & Links

Links to other databases for S-(2-aminoethyl)-L-cysteine

ChEBI
PubChem
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PubChem