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Ligand icariin

Basic Ligand Information

Molecular Structure

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Natural Substrate (2 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.2.1.108

icariin + H2O = ? + D-glucose

732550

-

3.7.1.4

icariin + H2O = ?

732550

-

Substrate in Enzyme-catalyzed Reactions (2 results)

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Show Substrate (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.2.1.108

icariin + H2O = ? + D-glucose

732550

-

3.7.1.4

icariin + H2O = ?

732550

-

Product in Enzyme-catalyzed Reactions (1 result)

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Show Product (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

3.2.1.40

epimedin C + H2O = icariin + alpha-L-rhamnopyranose

0

-

Inhibitor in Enzyme-catalyzed Reactions (1 result)

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Show Inhibitors (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.3.1.9

inhibitor identified by in silico screening, MIC value 0.1 mg/ml

763368

-

Enzyme Kinetic Parameters

References & Links

Literature References (2)

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Show Reference (2 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

732550

24368601

A comparative study on the metabolism of Epimedium koreanum nakai-prenylated flavonoids in rats by an intestinal enzyme (lactase phlorizin hydrolase) and intestinal flora

2014

Zhou, J.; Chen, Y.; Wang, Y.; Gao, X.; Qu, D.; Liu, C.

Molecules

19

177-203

763368

28734205

Identification of Mycobacterium tuberculosis enoyl-acyl carrier protein reductase inhibitors A combined in-silico and in-vitro analysis

2017

Lone, M.Y.; Athar, M.; Gupta, V.K.; Jha, P.C.

J. Mol. Graph. Model.

76

172-180

Links to other databases for icariin

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Show Links (1 entry)

ChEBI

PubChem