Ligand Pyridine

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Basic Ligand Information

Molecular Structure
Picture of Pyridine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H5N
Pyridine
LCTONWCANYUPML-UHFFFAOYSA-M
Synonyms:
azine

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
S-adenosyl-L-methionine + pyridine = S-adenosyl-L-homocysteine + N-methylpyridinium
show the reaction diagram
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thiamine + pyridine = 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium + 4-methyl-5-(2-hydroxyethyl)thiazole
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
pyridine + H2O2 = pyridine N-oxide + H2O
show the reaction diagram
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S-adenosyl-L-methionine + pyridine = S-adenosyl-L-homocysteine + N-methylpyridinium
show the reaction diagram
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pyridine + H2O = ?
show the reaction diagram
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pyridine + H2O = ?
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
pyridine N-oxide + electron donor = pyridine + oxidized electron donor + H2O
show the reaction diagram
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N[(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosyl)onate]pyridinium + H2O = sialic acid + pyridine
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
at 25 mM restores activity inhibited by heteropyrimidine at 0.006 mM
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5 mM, activity of both isoenzymes is modestly enhanced
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activates reaction with Gly-Gly-ethyl ester and Gly-Gly-NH2, no effect on reaction with Gly-Phe-NH2
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Inhibitor in Enzyme-catalyzed Reactions (17 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
binding of this compounds to the active heme site inhibits the enzyme
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highly reduced activity of xanthine oxidase in the presence of pyridine, overview
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non-linear inhibition
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6.4% inhibition at 30 mM
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300 mM, about 50% inhibition
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about 17% inhibition at 0.1 mM
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non-competitive inhibition of mutant E218A by pyridine
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upon permeabilization
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3D Structure of Enzyme-Ligand-Complex (PDB) (4 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (2 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (6 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.4
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References & Links

Links to other databases for Pyridine

ChEBI
PubChem
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PubChem