Ligand pterin

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Basic Ligand Information

Molecular Structure
Picture of pterin (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H5N5O
pterin
HNXQXTQTPAJEJL-UHFFFAOYSA-N
Synonyms:
2-Amino-4-hydroxypteridine, 2-aminopteridin-4(1H)-one, 2-aminopteridin-4(3H)-one, 7,8-dihydropterin, a 2-amino-4-hydroxypteridine, dihydropterin, Pterine, quinoid 7,8-dihydropterin, quinonoid-7,8-dihydropterin, quinonoid 7,8-dihydropterin
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-amino-4-hydroxypteridine + O2 = 2-amino-4,7-dihydroxypteridine + ?
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (15 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2-amino-4-hydroxypteridine + O2 = 2-amino-4,7-dihydroxypteridine + ?
show the reaction diagram
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pterin + NADPH = 7,8-dihydropterin + NADP+
show the reaction diagram
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7,8-dihydropterin + H2O = 7,8-dihydrolumazine + NH3
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + dihydropterin + H2O
show the reaction diagram
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pterin + NADPH = 7,8-dihydropterin + NADP+
show the reaction diagram
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4a-hydroxy-tetrahydropterin = 7,8-dihydropterin + H2O
show the reaction diagram
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Enzyme Cofactor/Cosubstrate (13 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
an electron transfer pathway is proposed that begins at the tungsten center, leads to the (4Fe-4S) cluster of formaldehyde ferredoxin oxidoreductase via one of the two pterins that coordinate the tungsten, and ends at the (4Fe-4S) cluster of ferredoxin. This pathway includes two residues that coordinate the (4Fe4S) clusters, Cys287 of FOR and Asp14 of ferredoxin
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inequivalent P- and Q-pterins coordinated to the molybdenum ion, structure analysis
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Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
activates
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Inhibitor in Enzyme-catalyzed Reactions (12 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
0.05 mM: 18% inhibition; 18% inhibition of the reductive reaction at 0.05 mM
-
pterin strongly inhibits guanine deaminase activity (57.8% inhibition at 1 mM), whereas it has a weak effect on dihydropterin deaminase activity
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3D Structure of Enzyme-Ligand-Complex (PDB) (46 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (4 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
16.3
-
in 100 mM potassium phosphate buffer (pH 7.5), at 40°C

KM Value (11 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.03
-
pH 6.5, 37°C
1.621
-
in 100 mM potassium phosphate buffer (pH 7.5), at 40°C

Ki Value (7 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.0022
-
37°C, pH 7.3

References & Links

Links to other databases for pterin

ChEBI
PubChem
ChEBI
PubChem