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Ligand GDP-D-mannuronate

Basic Ligand Information

Molecular Structure

Related pathways

Show all BRENDA pathways known for GDP-D-mannuronate

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.33

GDP-D-mannuronate + (alginate)n = GDP + (alginate)n+1

489052

-

In Vivo Product in Enzyme-catalyzed Reactions (6 results)

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Show Natural Product (6 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.132

GDP-D-mannose + NAD+ + H2O = GDP-D-mannunorate + NADH

-

1MFZ, 3D-view

1.1.1.132

GDP-D-mannose + NAD+ + H2O = GDP-D-mannunorate + NADH

-

1MUU, 3D-view

1.1.1.132

GDP-D-mannose + NAD+ + H2O = GDP-D-mannunorate + NADH

-

1MV8, 3D-view

1.1.1.132

GDP-D-mannose + NAD+ + H2O = GDP-D-mannuronate + NADH + H+

-

1MFZ, 3D-view

1.1.1.132

GDP-D-mannose + NAD+ + H2O = GDP-D-mannuronate + NADH + H+

-

1MUU, 3D-view

1.1.1.132

GDP-D-mannose + NAD+ + H2O = GDP-D-mannuronate + NADH + H+

-

1MV8, 3D-view

1.1.1.132

6 entries

Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Substrate (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.4.1.33

GDP-D-mannuronate + (alginate)n = GDP + (alginate)n+1

489052, 671458

-

Product in Enzyme-catalyzed Reactions (15 results)

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Show Product (15 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.132

GDP-D-mannose + NAD+ + H2O = GDP-D-mannunorate + NADH

-

1MFZ, 3D-view

1.1.1.132

GDP-D-mannose + NAD+ + H2O = GDP-D-mannunorate + NADH

-

1MUU, 3D-view

1.1.1.132

GDP-D-mannose + NAD+ + H2O = GDP-D-mannunorate + NADH

-

1MV8, 3D-view

1.1.1.132

GDP-D-mannose + 2 NAD+ + H2O = GDP-D-mannuronate + 2 NADH + 2 H+

-

1MFZ, 3D-view

1.1.1.132

GDP-D-mannose + 2 NAD+ + H2O = GDP-D-mannuronate + 2 NADH + 2 H+

-

1MUU, 3D-view

1.1.1.132

GDP-D-mannose + 2 NAD+ + H2O = GDP-D-mannuronate + 2 NADH + 2 H+

-

1MV8, 3D-view

1.1.1.132

GDP-D-mannose + NAD+ + H2O = GDP-D-mannuronate + NADH

-

1MFZ, 3D-view

1.1.1.132

GDP-D-mannose + NAD+ + H2O = GDP-D-mannuronate + NADH

-

1MUU, 3D-view

1.1.1.132

GDP-D-mannose + NAD+ + H2O = GDP-D-mannuronate + NADH

-

1MV8, 3D-view

1.1.1.132

GDP-D-mannose + NAD+ + H2O = GDP-D-mannuronate + NADH + H+

-

1MFZ, 3D-view

1.1.1.132

GDP-D-mannose + NAD+ + H2O = GDP-D-mannuronate + NADH + H+

-

1MUU, 3D-view

1.1.1.132

GDP-D-mannose + NAD+ + H2O = GDP-D-mannuronate + NADH + H+

-

1MV8, 3D-view

1.1.1.132

GDP-mannose + NAD+ + H2O = GDP-mannuronate + NADH

285836, 285837, 285838, 285842, 285830, 285832, 285833, 285839, 285840, 285841, 285834, 285831, 285829, 285835

1MFZ, 3D-view

1.1.1.132

GDP-mannose + NAD+ + H2O = GDP-mannuronate + NADH

285836, 285837, 285838, 285842, 285830, 285832, 285833, 285839, 285840, 285841, 285834, 285831, 285829, 285835

1MUU, 3D-view

1.1.1.132

GDP-mannose + NAD+ + H2O = GDP-mannuronate + NADH

285836, 285837, 285838, 285842, 285830, 285832, 285833, 285839, 285840, 285841, 285834, 285831, 285829, 285835

1MV8, 3D-view

1.1.1.132

15 entries

3D Structure of Enzyme-Ligand-Complex (PDB) (16 results)

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Show 3D Structure of Enzyme-Ligand-Complex (PDB) (16 entries)

EC NUMBER

ENZYME 3D STRUCTURE

1.1.1.132

1MFZ, 3D-view

1.1.1.132

1MUU, 3D-view

1.1.1.132

1MV8, 3D-view

1.1.1.132

1MFZ, 3D-view

1.1.1.132

1MUU, 3D-view

1.1.1.132

1MV8, 3D-view

1.1.1.132

1MFZ, 3D-view

1.1.1.132

1MUU, 3D-view

1.1.1.132

1MV8, 3D-view

1.1.1.132

1MFZ, 3D-view

1.1.1.132

1MUU, 3D-view

1.1.1.132

1MV8, 3D-view

1.1.1.132

1MFZ, 3D-view

1.1.1.132

1MUU, 3D-view

1.1.1.132

1MV8, 3D-view

1.1.1.132

15 entries

2.4.1.217

2Y4M, 3D-view

Enzyme Kinetic Parameters

References & Links

Literature References (16)

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Show Reference (16 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

285829

-

GDP-mannose dehydrogenase from Arthrobacter

1966

Preiss, J.

Methods Enzymol.

8

285-287

285830

2470755

Purification and characterization of guanosine diphospho-D-mannose dehydrogenase. A key enzyme in the biosynthesis of alginate by Pseudomonas aeruginosa

1989

Roychoudhury, S.; Mmay, T.B.; Gill, J.F.; Singh, S.K.; Feingold, D.S.; Chakrabarty, A.M.

J. Biol. Chem.

264

9380-9385

285831

14245351

Sugar nucleotide reactions in Arthrobacter. II. Biosynthesis of guanosine diphosphomannuronate

1964

Preiss, J.

J. Biol. Chem.

239

3127-3132

285832

6185463

GDPmannose dehydrogenase and biosynthesis of alginate-like polysaccharide in a mucoid strain of Pseudomonas aeruginosa

1983

Pugashetti, B.K.; Vadas, L.; Prihar, H.S.; Feingold, D.S.

J. Bacteriol.

153

1107-1110

285833

3025179

Gene algD coding for GDPmannose dehydrogenase is transcriptionally activated in mucoid Pseudomonas aeruginosa

1987

Deretic, V.; Gill, J.F.; Chakrabarty, A.M.

J. Bacteriol.

169

351-358

285834

-

Studies on some enzymes of alginic acid biosynthesis in Azotobacter vinelandii grown in continuous culture

1983

Horan, N.J.; Jarman, T.R.; Dawes, E.A.

J. Gen. Microbiol.

129

2985-2990

285835

1080387

Polysaccharide production and the possible occurrence of GDP-D-mannose dehydrogenase in Azotobacter vinelandii

1975

Couperwhite, I.; McCallum, M.F.

Antonie van Leeuwenhoek

41

25-32

285836

10209766

Pattern of changes in the activity of enzymes of GDP-D-mannuronic acid synthesis and in the level of transcription of algA, algC and algD genes accompanying the loss and emergence of mucoidy in Pseudomonas aeruginosa

1999

Tavares, I.M.; Leitao, J.H.; Fialho, A.M.; Sa-Correia, I.

Res. Microbiol.

150

105-116

285837

1367514

Alginate biosynthesis in mucoid recombinants of Pseudomonas aeruginosa overproducing GDP-mannose dehydrogenase

1991

Martins, L.O.; Sa-Correia, I.

Enzyme Microb. Technol.

13

385-389

285838

8878949

Overexpression of the GDP-mannose dehydrogenase gene from Pseudomonas aeruginosa

1996

Tatnell, P.J.; Russell, N.J.; Gacesa, P.

Biochem. Soc. Trans.

24

405S

285839

-

Inhibitors of GDP-mannose dehydrogenase of Pseudomonas aeruginosa mucoid strains

1992

Elloumi, N.; Moreau, B.; Aguiar, L.; Jaziri, N.; Sauvage, M.; Hulen, C.; Capmau, M.L.

Eur. J. Med. Chem.

27

149-154

285840

1370473

Characterization of guanosine diphospho-D-mannose dehydrogenase from Pseudomonas aeruginosa. Structural analysis by limited proteolyses

1992

Roychoudhury, S.; Chakrabarty, K.; Ho, Y.K.; Chakrabarty, A.M.

J. Biol. Chem.

267

990-996

285841

11810531

Influence of macrolides on guanosine diphospho-D-mannose dehydrogenase activity in Pseudomonas biofilm

2000

Mitsuya, Y.; Kawai, S.; Kobayashi, H.

J. Infect. Chemother.

6

45-50

285842

7521247

GDP-mannose dehydrogenase is the key regulatory enzyme in alginate biosynthesis in Pseudomonas aeruginosa: evidence from metabolite studies

1994

Tatnell, P.J.; Russell, N.J.; Gacesa, P.

Microbiology

140

1745-1754

489052

5954796

Pathway of alginic acid synthesis in the marine brown alga, Fucus gardneri Silva

1966

Lin, T.Y.; Hassid, W.Z.

J. Biol. Chem.

241

5284-5297

671458

16391057

In vitro alginate polymerization and the functional role of Alg8 in alginate production by Pseudomonas aeruginosa

2006

Remminghorst, U.; Rehm, B.H.

Appl. Environ. Microbiol.

72

298-305

Links to other databases for GDP-D-mannuronate

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Show Links (1 entry)