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Ligand gamma-linolenoyl-CoA

Basic Ligand Information

Molecular Structure

Show all BRENDA pathways known for gamma-linolenoyl-CoA

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Roles as Enzyme Ligand

In Vivo Product in Enzyme-catalyzed Reactions (3 results)

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Show Natural Product (3 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.19.3

linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O

0

-

1.14.19.3

linoleoyl-CoA + AH2 + O2 = gamma-linolenoyl-CoA + A + 2 H2O

0

-

1.14.19.3

linoleoyl-CoA + ferrocytochrome b5 + O2 + H+ = gamma-linolenoyl-CoA + ferricytochrome b5 + H2O

0

-

1.14.19.3

3 entries

Substrate in Enzyme-catalyzed Reactions (6 results)

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Show Substrate (6 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.20

gamma-linolenoyl-CoA + 1,2-diacyl-sn-glycerol = CoA + 1,2-diacyl-3-gamma-linolenoylglycerol

758011, 757276

-

2.3.1.62

gamma-linolenoyl-CoA + 2-acyl-sn-glycero-3-phosphocholine = CoA + 1-gamma-linolenoyl-2-acyl-sn-glycero-3-phosphocholine

487352

-

2.3.1.75

octadecatrienoyl-CoA + hexadecan-1-ol = ?

756245

-

2.3.1.75

octadecatrienoyl-CoA + hexadecanol = CoA + hexadecyl octadecatrienoate

756245

-

2.3.1.75

2 entries

3.1.2.2

gamma-linolenoyl-CoA + H2O = CoA + gamma-linolenoate

646169, 646194

-

3.1.2.20

gamma-linolenoyl-CoA + H2O = CoA + gamma-linolenoate

646169, 646194

-

Product in Enzyme-catalyzed Reactions (4 results)

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Show Product (4 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.19.3

linoleoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = gamma-linolenoyl-CoA + 2 ferricytochrome b5 + 2 H2O

0

-

1.14.19.3

linoleoyl-CoA + AH2 + O2 = gamma-linolenoyl-CoA + A + 2 H2O

0

-

1.14.19.3

linoleoyl-CoA + ferrocytochrome b5 + O2 + H+ = gamma-linolenoyl-CoA + ferricytochrome b5 + H2O

0

-

1.14.19.3

3 entries

6.2.1.3

ATP + (6Z,9Z,12Z)-octadecatrienoate + CoA = AMP + diphosphate + (6Z,9Z,12Z)-octadecatrienoyl-CoA

653493

-

Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (4 results)

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Show Turnover Number (4 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

2.3.1.75

0.0236

-

isoform WSD4, at pH 7.4 and 37°C

756245

2.3.1.75

0.0236

-

pH 7.4, 37°C, recombinant enzyme

756245

2.3.1.75

0.242

-

isoform WSD5, at pH 7.4 and 37°C

756245

2.3.1.75

0.242

-

pH 7.4, 37°C, recombinant enzyme

756245

2.3.1.75

4 entries

K_M Value (4 results)

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Show KM Value (4 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.3.1.75

0.28086

-

isoform WSD4, at pH 7.4 and 37°C

756245

2.3.1.75

0.2809

-

pH 7.4, 37°C, recombinant enzyme

756245

2.3.1.75

0.28468

-

isoform WSD5, at pH 7.4 and 37°C

756245

2.3.1.75

0.2847

-

pH 7.4, 37°C, recombinant enzyme

756245

2.3.1.75

4 entries

References & Links

Literature References (7)

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Show Reference (7 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

487352

6704412

Mechanism for adaptive modification during cold acclimation of phospholipid acyl chain composition in Tetrahymena. II. Activities of 2-acyl-sn-glycerol-3-phosphorylcholine and 2-acyl-sn-glycerol-3-phosphorylethanolamine acyltransferases involving the reacylation

1984

Yoshioka, S.; Kameyama, Y.; Nozawa, Y.

Biochim. Biophys. Acta

793

34-41

646169

7909756

Characterization of microsomal long-chain acyl-CoA hydrolase activity in the rat submandibular gland

1994

Shin, S.O.; Kameyama, Y.; Yoshida, M.; Takatsu, F.; Shinkai, A.; Inokuchi, H.; Saito, Y.; Yokota, Y.

Int. J. Biochem.

26

279-285

646194

12538089

Acyl-CoA thioesterase activity in human placental choriocarcinoma (BeWo), cells: effects of fatty acids

2003

Duttaroy, A.K.; Crozet, D.; Taylor, J.; Gordon, M.J.

Prostaglandins

68

43-48

653493

11785933

Characterization of a novel plant acyl-coA synthetase that is expressed in lipogenic tissues of Brassica napus L

2001

Pongdontri, P.; Hills, M.

Plant Mol. Biol.

47

717-726

756245

28725265

Two bifunctional enzymes from the marine protist Thraustochytrium roseum biochemical characterization of wax ester synthase/acyl-CoA diacylglycerol acyltransferase activity catalyzing wax ester and triacylglycerol synthesis

2017

Zhang, N.; Mao, Z.; Luo, L.; Wan, X.; Huang, F.; Gong, Y.

Biotechnol. Biofuels

10

185

757276

29050877

Diacylglycerol acyltransferase 2 of Mortierella alpina with specificity on long-chain polyunsaturated fatty acids a potential tool for reconstituting lipids with nutritional value

2017

Jeennor, S.; Veerana, M.; Anantayanon, J.; Panchanawaporn, S.; Chutrakul, C.; Laoteng, K.

J. Biotechnol.

263

45-51

758011

26919811

Characterization of type 2 diacylglycerol acyltransferases in Chlamydomonas reinhardtii reveals their distinct substrate specificities and functions in triacylglycerol biosynthesis

2016

Liu, J.; Han, D.; Yoon, K.; Hu, Q.; Li, Y.

Plant J.

86

3-19

Links to other databases for gamma-linolenoyl-CoA

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Show Links (1 entry)

ChEBI

PubChem