Ligand [Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine
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Basic Ligand Information
[Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)
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[Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine + H2O = [Wnt]-L-serine + (9Z)-hexadec-9-enoate
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In Vivo Product in Enzyme-catalyzed Reactions (1 result)
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(9Z)-hexadec-9-enoyl-CoA + [Wnt]-L-serine = CoA + [Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine
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Substrate in Enzyme-catalyzed Reactions (1 result)
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[Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine + H2O = [Wnt]-L-serine + (9Z)-hexadec-9-enoate
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Product in Enzyme-catalyzed Reactions (1 result)
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(9Z)-hexadec-9-enoyl-CoA + [Wnt]-L-serine = CoA + [Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine
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Enzyme Kinetic Parameters
References & Links
Literature References (3)
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Notum is required for neural and head induction via Wnt deacylation, oxidation, and inactivation
2015
Zhang, X.; Cheong, S.M.; Amado, N.G.; Reis, A.H.; MacDonald, B.T.; Zebisch, M.; Jones, E.Y.; Abreu, J.G.; He, X.
Dev. Cell
32
719-730
Notum deacylates Wnt proteins to suppress signalling activity
2015
Kakugawa, S.; Langton, P.F.; Zebisch, M.; Howell, S.A.; Chang, T.H.; Liu, Y.; Feizi, T.; Bineva, G.; OReilly, N.; Snijders, A.P.; Jones, E.Y.; Vincent, J.P.
Nature
519
187-192
Selective irreversible inhibitors of the Wnt-deacylating enzyme NOTUM developed by activity-based protein profiling
2018
Suciu, R.M.; Cognetta, A.B.; Potter, Z.E.; Cravatt, B.F.
ACS Med. Chem. Lett.
9
563-568
Links to other databases for [Wnt]-O-(9Z)-hexadec-9-enoyl-L-serine