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Ligand (S)-5-amino-3-oxohexanoate

Basic Ligand Information

Molecular Structure

Show all BRENDA pathways known for (S)-5-amino-3-oxohexanoate

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Natural Substrate (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.247

(5S)-5-amino-3-oxohexanoate + acetyl-CoA = L-3-aminobutanoyl-CoA + acetoacetate

6044, 3378, 680885, 734167

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In Vivo Product in Enzyme-catalyzed Reactions (1 result)

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Show Natural Product (1 entry)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.4.1.B2

L-erythro-3,5-diaminohexanoate + H2O + NADP+ = (S)-5-amino-3-oxohexanoate + NH3 + NADPH + H+

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Substrate in Enzyme-catalyzed Reactions (1 result)

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Show Substrate (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.3.1.247

(5S)-5-amino-3-oxohexanoate + acetyl-CoA = L-3-aminobutanoyl-CoA + acetoacetate

6044, 3378, 680885, 734167

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Product in Enzyme-catalyzed Reactions (1 result)

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Show Product (1 entry)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.4.1.B2

L-erythro-3,5-diaminohexanoate + H2O + NADP+ = (S)-5-amino-3-oxohexanoate + NH3 + NADPH + H+

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Enzyme Kinetic Parameters

k_cat Value (Turnover Number) (4 results)

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Show Turnover Number (4 entries)

EC NUMBER

TURNOVER NUMBER [1/S]

TURNOVER NUMBER MAXIMUM [1/S]

COMMENTARY

LITERATURE

2.3.1.247

0.13

-

mutant S82G, pH and temperature not specified in the publication

734167

2.3.1.247

0.32

-

mutant E143Q, pH and temperature not specified in the publication

734167

2.3.1.247

0.37

-

mutant E143G, pH and temperature not specified in the publication

734167

2.3.1.247

2.69

-

wild-type enzyme, pH and temperature not specified in the publication

734167

2.3.1.247

4 entries

K_M Value (4 results)

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Show KM Value (4 entries)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

2.3.1.247

0.208

-

wild-type enzyme, pH and temperature not specified in the publication

734167

2.3.1.247

0.442

-

mutant E143Q, pH and temperature not specified in the publication

734167

2.3.1.247

0.921

-

mutant E143G, pH and temperature not specified in the publication

734167

2.3.1.247

1.181

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mutant S82G, pH and temperature not specified in the publication

734167

2.3.1.247

4 entries

References & Links

Literature References (4)

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Show Reference (4 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

3378

6811551

Pathway of lysine degradation in Fusobacterium nucleatum

1982

Barker, H.A.; Kahn, J.M.; Hedrick, L.

J. Bacteriol.

152

201-207

6044

7410315

Enzymes involved in 3,5-diaminohexanoate degradation by Brevibacterium sp.

1980

Barker, H.A.; Kahn, J.M.; Chew, S.

J. Bacteriol.

143

1165-1170

680885

17166837

Identification of the last unknown genes in the fermentation pathway of lysine

2007

Kreimeyer, A.; Perret, A.; Lechaplais, C.; Vallenet, D.; Medigue, C.; Salanoubat, M.; Weissenbach, J.

J. Biol. Chem.

282

7191-7197

734167

21632536

3-Keto-5-aminohexanoate cleavage enzyme: a common fold for an uncommon Claisen-type condensation

2011

Bellinzoni, M.; Bastard, K.; Perret, A.; Zaparucha, A.; Perchat, N.; Vergne, C.; Wagner, T.; de Melo-Minardi, R.C.; Artiguenave, F.; Cohen, G.N.; Weissenbach, J.; Salanoubat, M.; Alzari, P.M.

J. Biol. Chem.

286

27399-27405

Links to other databases for (S)-5-amino-3-oxohexanoate

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Show Links (1 entry)

ChEBI

PubChem

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