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Ligand DL-Ornithine Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information Molecular Structure
C5 H1 2 N2 O2
DL-Ornithine
AHLPHDHHMVZTML-UHFFFAOYSA-N
2,5-Diaminopentanoate, 2,5-diaminopentanoic acid, D-/L-Ornithine, Polyornithine
Roles as Enzyme Ligand
Substrate in Enzyme-catalyzed Reactions (2 results)
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DL-ornithine + 2-oxoglutarate = L-glutamate + 4-methyl-2-oxopentanoate
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DL-ornithine = (2R,4S)-2,4-diaminopentanoate
-
Product in Enzyme-catalyzed Reactions (2 results)
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dichloroacetyl-DL-ornithine + H2O = dichloroacetate + DL-ornithine
-
-
arginine + H2O = 2,5-diaminopentanoate + urea
-
-
Activator in Enzyme-catalyzed Reactions (2 results)
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stimulation, 112% of non-stimulated activity
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stimulation of poly(A) synthesis, phosphorolysis of poly(A) is inhibited
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Inhibitor in Enzyme-catalyzed Reactions (2 results)
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competitive inhibition, 10 mM
-
Enzyme Kinetic Parameters
kcat Value (Turnover Number) (3 results)
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0.0023
-
pH 8.5, 20°C, recombinant beta-subunit mutant Y187A
0.115
-
pH 8.5, 20°C, recombinant beta-subunit mutant Y187F
2.9
-
pH 8.5, 20°C, recombinant wild-type enzyme
KM Value (3 results)
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0.068
-
pH 8.5, 20°C, recombinant beta-subunit mutant Y187A
0.162
-
pH 8.5, 20°C, recombinant beta-subunit mutant Y187F
0.567
-
pH 8.5, 20°C, recombinant wild-type enzyme
References & Links Literature References (7)
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Kynureninase from Neurospora: Interaction of enzyme with substrates, coenzyme, and amines
1953
Jacoby, W.B.; Bonner, D.M.
J. Biol. Chem.
205
709-715
gamma-Aminobutyrate:alpha-ketoglutarate aminotransferase from Pseudomonas sp. F-126: purification, crystallization, and enzymologic properties
1980
Yonaha, K.; Toyama, S.
Arch. Biochem. Biophys.
200
156-164
4-Aminobutyrate:2-oxoglutarate aminotransferase of Streptomyces griseus: purification and properties
1985
Yonaha, K.; Suzuki, K.; Toyama, S.
Eur. J. Biochem.
146
101-106
-
Studies on vitamin b6 metabolism in microorganisms. Part X. Further purification and characterization of pyridoxamine 5'-phosphate-alpha-ketoglutarate transaminase from Clostridium kainantoi
1972
Tani, Y.; Ukita, M.; Ogata, K.
Agric. Biol. Chem.
36
181-188
Activity of Foot-and-mouth disease virus RNA-dependent RNA polymerase in vitro: inhibition by polyamines and poly(amino acid)s
1973
Lazarus, L.H.; Itin, A.
Arch. Biochem. Biophys.
156
154-160
-
Polynucleotide phosphorylase
1982
Littauer, U.Z.; Soreq, H.
The Enzymes, 3rd. Ed. (Boyer, P. D. , ed. )
15B
517-553
Isotope effects for deuterium transfer and mutagenesis of Tyr187 provide insight into controlled radical chemistry in adenosylcobalamin-dependent ornithine 4,5-aminomutase
2014
Makins, C.; Whitelaw, D.A.; Mu, C.; Walsby, C.J.; Wolthers, K.R.
Biochemistry
53
5432-5443
Links to other databases for DL-Ornithine
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